Doplet-3 Injection 5 mg/mL (Cholecalciferol / Vitamin D3) — 1 Ampoule

Description

Doplet-3 is an injectable formulation of cholecalciferol (Vitamin D3) at 5 mg per mL, intended for intramuscular (IM) or subcutaneous (SC) use to rapidly correct vitamin D deficiency, especially when oral absorption is inadequate or in patients who need parenteral vitamin D supplementation. 

Ingredients

• Active ingredient: Cholecalciferol (Vitamin D3) — 5 mg/mL

• Excipients / vehicle: Manufacturer-specific solvent and stabilizers (as per product leaflet) 

Drug Class

• Vitamin / Nutritional supplement (Fat-soluble vitamin D group)

Dosage Form

• Sterile solution in 1 mL ampoule for injection

Uses / Indications

Doplet-3 injection is used for:

• Treatment of vitamin D deficiency or insufficiency 

• Prevention / therapy of rickets, osteomalacia, osteoporosis, or bone demineralization 

• Situations where oral vitamin D is poorly tolerated, absorption is impaired, or rapid correction is needed 

Dosage

• The exact dose and schedule should be determined by a healthcare provider based on serum vitamin D levels, clinical status, and patient factors.

• Common approach: a high dose injection (e.g. 5 mg = 200,000 IU equivalent) given as single or repeated injections under monitoring.

• Maintenance oral vitamin D / supplementation often continues after injection.

In Case of Overdose

• Excess vitamin D can lead to hypercalcemia: nausea, vomiting, weakness, frequent urination, dehydration, confusion, arrhythmias, kidney damage

• Management: discontinue further supplementation, restrict calcium, provide IV hydration, possibly corticosteroids or bisphosphonates under physician direction

Missed Dose

• Since this is often an infrequent injection, a “missed dose” protocol is less relevant

• If missed, follow physician advice — do not double the next dose to compensate

How To Use / Administration Instructions

1. Inspect ampoule: the solution should be clear, colorless, and free of particles

2. Use aseptic technique to open and draw up the dose in a sterile syringe

3. Administer via intramuscular (IM) injection (or SC if approved)

4. Injection should be done by a qualified healthcare professional

5. Avoid rapid injection to reduce discomfort

When Not to Use / Contraindications

• Known hypersensitivity to cholecalciferol or formulation excipients

• Hypercalcemia or hypercalciuria

• Disorders with risk of vitamin D excess (e.g. sarcoidosis, certain granulomatous diseases)

• Renal impairment with reduced excretory capacity (unless under specialist guidance)

Side Effects / Adverse Reactions

Common / mild:

• Injection site reactions (pain, swelling)

• Nausea, vomiting, constipation

• Weakness, fatigue

Serious / rare:

• Signs of hypercalcemia (as above)

• Soft tissue or vascular calcification

• Allergic reactions (rash, swelling, difficulty breathing)

• Cardiac arrhythmias in severe cases

Precautions & Warnings

• Monitor serum calcium, phosphate, and renal function periodically

• Use with caution in patients with renal disease, and avoid concomitant high-dose calcium without supervision

• Avoid overlapping high-dose oral vitamin D or supplements without physician oversight

• Pregnant/lactating women: only use if benefits justify risk and under medical supervision

Drug Interactions

• Thiazide diuretics: may increase risk of hypercalcemia

• Corticosteroids: may antagonize vitamin D absorption or effects

• Certain anticonvulsants (e.g. phenytoin, phenobarbital): may accelerate vitamin D metabolism

• Magnesium deficiency, proton pump inhibitors, etc.: may affect absorption/metabolism

Storage / Disposal

• Store ampoules in original packaging, protected from light and heat, at recommended temperature

• Do not freeze

• Use ampoule immediately after opening; do not reuse

• Dispose of used ampoule and needles in sharps / medical waste container

Control Drug / Prescription Status

• Prescription-only (i.e. cannot be sold over the counter)

• Administered under medical supervision

Quick Tips

• Doplet-3 is a high-potency injectable vitamin D3, useful for rapid correction in deficiency states

• Always measure serum 25-hydroxyvitamin D and calcium before repeating injections

• Avoid using multiple vitamin D sources simultaneously without monitoring

• Inform patients to report symptoms of hypercalcemia (thirst, bone pain, weakness, confusion)

• Keep a log of batch, date, and dose administered