Calamox 1.2 g Injection (Amoxicillin + Clavulanic Acid) – Broad Spectrum Antibiotic

Description

Calamox Injection is a broad-spectrum antibiotic containing amoxicillin (a penicillin-type antibiotic) and clavulanic acid (a β-lactamase inhibitor). The addition of clavulanic acid helps prevent bacterial resistance by inhibiting β-lactamase enzymes, making the combination more effective against resistant strains. It is widely used in the treatment of moderate to severe bacterial infections.

Ingredients

• Active ingredients:

  • Amoxicillin sodium equivalent to 1 g of amoxicillin

  • Clavulanic acid (as potassium clavulanate) equivalent to 200 mg

• Excipients: sterile additives as per manufacturer

Drug Class

• Antibiotic – Penicillin (β-lactam) + β-lactamase inhibitor

Dosage Form

• Powder for injection

• To be reconstituted for intravenous (IV) or intramuscular (IM) administration

Uses / Indications

Calamox is indicated for treatment of infections caused by susceptible bacteria, including:

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections

• Skin and soft tissue infections

• Intra-abdominal infections

• Bone and joint infections

• Gynecological infections

• Sepsis and other systemic infections

Dosage (general guidance, individualized by physician)

• Adults & adolescents (≥40 kg): 1.2 g every 8 hours by IV or IM injection. In severe infections, may be given every 6 hours.

• Children (≤40 kg): dose is usually 30 mg/kg every 8 hours (based on amoxicillin component).

• Renal impairment: dose adjustments required.

• Administer for the shortest effective duration as advised by the doctor.

In Case of Overdose

• Symptoms: nausea, vomiting, diarrhea, imbalance of fluids/electrolytes, seizures (rare).

• Management: supportive care, correction of fluid balance, and hemodialysis if necessary (drug is dialyzable).

Missed Dose

• If a dose is missed (in hospital), it should be given as soon as possible.

• Do not double the next dose to make up for a missed one.

How To Use

1. Reconstitute the vial with recommended diluent (sterile water for injection or compatible IV fluid).

2. Administer slowly by IV injection or infusion, or deep IM injection.

3. Always use aseptic precautions.

4. Discard unused solution after recommended stability period.

When Not to Use (Contraindications)

• Hypersensitivity to penicillins, cephalosporins, or β-lactam antibiotics

• History of severe allergic reaction (e.g., anaphylaxis) to β-lactams

• History of jaundice or liver dysfunction associated with previous amoxicillin/clavulanic acid use

Side Effects

Common:

• Diarrhea, nausea, vomiting

• Local pain, swelling at injection site

• Rash, itching

Uncommon / rare:

• Liver enzyme elevation, jaundice

• Allergic reactions (urticaria, angioedema, anaphylaxis)

• Clostridioides difficile–associated diarrhea (serious, requires medical attention)

• Blood disorders (thrombocytopenia, anemia, leukopenia)

Precautions & Warnings

• Monitor liver and kidney function during prolonged therapy

• Use cautiously in patients with renal impairment or hepatic dysfunction

• Risk of superinfection with prolonged use

• Patients with history of allergy (asthma, hay fever, drug allergies) are at higher risk of hypersensitivity

• Avoid unnecessary use to reduce risk of antibiotic resistance

Drug Interactions

• Allopurinol: may increase risk of rash

• Oral anticoagulants (e.g., warfarin): enhanced effect, monitor INR

• Methotrexate: toxicity risk increased (reduced clearance)

• Other antibiotics (e.g., tetracyclines, macrolides): may interfere with effectiveness

• Probenecid: increases blood levels of amoxicillin

Storage / Disposal

• Store in a cool, dry place, below 25°C, in original packaging

• Protect from light and moisture

• After reconstitution: use immediately or within the time specified by manufacturer

• Dispose of unused vials as per hospital/clinic biomedical waste protocols

Control Drug / Prescription Status

• Prescription-only medicine

• To be administered by trained healthcare professionals only

Quick Tips

• Calamox covers more resistant bacteria than plain amoxicillin, thanks to clavulanic acid

• Complete the full antibiotic course, even if symptoms improve early

• Report persistent diarrhea or signs of liver problems immediately

• Not suitable for self-injection; must be given under medical supervision

• Inform your doctor if you are on anticoagulants or methotrexate