Description:
Duragesic 35/450mg Tablets provide effective relief from moderate to severe pain by combining Tramadol Hydrochloride (an opioid-like analgesic) with Paracetamol (Acetaminophen) (a non-opioid pain reliever and fever reducer).
This dual-action formula helps relieve pain from conditions such as muscle injuries, arthritis, post-surgical pain, and chronic back pain. Tramadol acts on the central nervous system to reduce pain perception, while Paracetamol enhances its pain-relieving effects and lowers fever.
Duragesic offers fast, long-lasting pain control and is suitable for short-term use under medical supervision.
Ingredients:
Each tablet contains:
Inactive Ingredients:
Microcrystalline cellulose, maize starch, magnesium stearate, and purified water.
Drug Class:
Dosage Form:
Uses:
Duragesic Tablets are indicated for:
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Moderate to severe pain (acute or chronic)
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Post-operative pain management
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Muscle and joint pain
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Arthritis or osteoarthritis pain
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Dental pain
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Back and nerve pain
Dosage:
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Adults: 1–2 tablets every 4 to 6 hours as needed for pain.
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Maximum dose: Do not exceed 8 tablets per day (equivalent to 280 mg Tramadol and 3600 mg Paracetamol).
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Elderly or liver-impaired patients: Consult a physician for adjusted dosing.
💡 Always use the lowest effective dose for the shortest duration possible.
In Case of Overdose:
Symptoms: Nausea, vomiting, sweating, confusion, slow breathing, or loss of consciousness.
👉 Seek immediate medical help or go to the nearest emergency room.
Overdose can cause liver damage (from paracetamol) or respiratory depression (from tramadol).
Missed Dose:
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If a dose is missed, take it as soon as you remember.
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If it’s nearly time for your next dose, skip the missed one—do not double up.
How To Use:
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Take the tablet with water, with or without food.
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Do not crush, chew, or break the tablet.
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Take at the same time each day if used regularly.
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Avoid alcohol or sedative medications while taking Duragesic.
When Not to Use:
Do not take Duragesic if you:
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Are allergic to Tramadol, Paracetamol, or any other ingredient
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Have severe liver or kidney disease
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Are taking MAO inhibitors (antidepressants) or used them in the past 14 days
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Have severe breathing disorders or uncontrolled epilepsy
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Are under 12 years old or pregnant/breastfeeding (unless prescribed)
Side Effects:
Common:
Less Common but Serious:
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Shallow or slow breathing
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Severe skin rash or allergic reaction
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Liver toxicity (yellowing of skin/eyes, dark urine)
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Seizures
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Mood changes or confusion
👉 Seek medical help if you experience any severe or persistent symptoms.
Precautions & Warnings:
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Use with extreme caution in patients with liver or kidney impairment.
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Avoid alcohol—it increases drowsiness and liver toxicity risk.
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May cause drowsiness—avoid driving or operating machinery.
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Long-term use may lead to dependence or tolerance.
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Inform your doctor of all current medications, supplements, or herbal remedies.
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Stop using if you develop signs of allergic reaction (rash, itching, swelling).
Drug Interactions:
Duragesic may interact with:
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MAO inhibitors or SSRIs/SNRIs (risk of serotonin syndrome)
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Other opioids or sedatives (enhanced CNS depression)
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Warfarin (increased bleeding risk)
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Carbamazepine or rifampicin (reduce Tramadol effectiveness)
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Alcohol (increases liver damage risk)
Storage/Disposal:
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Store below 30°C in a cool, dry place.
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Keep in original blister pack to protect from moisture.
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Keep out of reach of children.
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Dispose of unused tablets properly—do not flush down the toilet.
Control Drug:
Quick Tips:
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Take exactly as prescribed—do not exceed the recommended dose.
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Avoid alcohol, sedatives, or recreational drugs.
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If used long-term, do not stop suddenly; taper off under doctor’s guidance.
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Maintain hydration and fiber intake to prevent constipation.
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Consult your doctor before use if you have liver, kidney, or breathing problems.
