Description:
Duragesic Forte 50/650mg Tablets are a powerful combination of Tramadol Hydrochloride (50 mg) and Paracetamol (Acetaminophen) (650 mg), formulated for the relief of moderate to severe pain.
This dual-action pain reliever works by targeting the central nervous system—Tramadol acts as an opioid-like analgesic to alter pain perception, while Paracetamol enhances pain relief and reduces fever.
Duragesic Forte is commonly prescribed for post-operative pain, arthritis, injury-related pain, dental pain, and muscle or joint pain, providing effective and sustained relief when standard painkillers are insufficient.
Ingredients:
Each tablet contains:
Inactive Ingredients:
Microcrystalline cellulose, magnesium stearate, maize starch, colloidal silicon dioxide, and purified water.
Drug Class:
Dosage Form:
Uses:
Duragesic Forte is used to relieve:
Dosage:
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Adults: 1–2 tablets every 4 to 6 hours as needed for pain.
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Do not exceed 8 tablets per day (equivalent to 400 mg Tramadol and 5200 mg Paracetamol).
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Elderly or patients with liver/kidney impairment: Lower doses may be required. Consult your physician.
💡 Always use the lowest effective dose for the shortest possible duration.
In Case of Overdose:
Symptoms: Nausea, vomiting, drowsiness, confusion, slow breathing, or yellowing of eyes/skin.
👉 Seek immediate medical attention. Overdose may cause liver toxicity (from paracetamol) or respiratory depression (from tramadol).
Do not self-treat or delay emergency care.
Missed Dose:
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Take as soon as you remember if needed for pain.
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If it’s close to your next scheduled dose, skip the missed one—do not double up.
How To Use:
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Take the tablet with a full glass of water, with or without food.
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Do not crush or chew—swallow whole.
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Take at the same times each day if using regularly.
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Avoid alcohol or sedatives, which increase drowsiness and overdose risk.
When Not to Use:
Avoid Duragesic Forte if you:
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Are allergic to Tramadol, Paracetamol, or similar medications
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Have severe liver or kidney disease
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Are using MAO inhibitors (or within 14 days of stopping them)
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Have breathing difficulties or severe asthma
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Have a history of seizures or epilepsy
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Are pregnant or breastfeeding (unless prescribed)
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Are under 12 years old
Side Effects:
Common:
Less Common but Serious:
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Slow or shallow breathing
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Severe skin rash
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Liver damage (yellow skin/eyes, dark urine)
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Seizures
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Confusion, hallucinations, or mood changes
👉 Stop the medication and seek medical help immediately if you notice any severe reaction.
Precautions & Warnings:
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Avoid alcohol—increases risk of liver toxicity and drowsiness.
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Use cautiously if you have liver, kidney, or respiratory problems.
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May cause dependence if used long-term—follow doctor’s advice strictly.
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Avoid driving or operating heavy machinery until you know how it affects you.
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Report any signs of allergic reaction or skin rash.
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Maintain hydration and fiber intake to prevent constipation.
Drug Interactions:
Duragesic Forte may interact with:
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MAO inhibitors, SSRIs, or SNRIs (risk of serotonin syndrome)
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Warfarin (increased bleeding risk)
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Other opioids or sedatives (enhanced CNS depression)
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Carbamazepine or Rifampicin (reduce tramadol effectiveness)
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Alcohol (increases liver and CNS side effects)
Storage/Disposal:
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Store below 30°C, away from moisture and sunlight.
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Keep in original packaging until use.
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Keep out of reach of children.
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Dispose of unused tablets responsibly; do not flush or burn.
Control Drug:
Quick Tips:
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Take only as directed by your doctor.
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Avoid alcohol or other sedatives.
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Do not exceed the daily dose limit—overdose can harm the liver.
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If used long-term, do not stop suddenly—taper gradually under supervision.
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Stay hydrated and eat fiber-rich foods to ease constipation.
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Inform your doctor about all other medicines you’re taking.
