Grasil Injection 100mg/2ml (Amikacin Sulfate) — 1 Vial

Description

Grasil (100mg) Injection contains Amikacin sulfate, an aminoglycoside antibiotic used to treat serious bacterial infections caused by gram-negative organisms and certain gram-positive bacteria. It is often reserved for infections resistant to other antibiotics, including sepsis, urinary tract infections, respiratory tract infections, intra-abdominal infections, and bone/joint infections.

Ingredients

• Active Ingredient: Amikacin Sulfate (100mg per 2ml vial)

• Excipients: Water for injection and stabilizers (as per manufacturer)

Drug Class

• Aminoglycoside Antibiotic

Dosage Form

• Injection (Intramuscular [IM] or Intravenous [IV])

Uses / Indications

• Severe bacterial infections caused by susceptible organisms

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections

• Intra-abdominal and pelvic infections

• Septicemia and bacteremia

• Bone and joint infections

• Skin and soft tissue infections

• Meningitis (as part of combination therapy)

Dosage

⚠️ Dose depends on infection severity, age, weight, and kidney function.

• Adults: 15 mg/kg/day IM or IV, in 2 divided doses (max 1.5 g/day).

• Children: 15–20 mg/kg/day in divided doses.

• Neonates & Premature Infants: Loading dose of 10 mg/kg, followed by 7.5 mg/kg every 12 hours.

• Duration: Usually 7–10 days, as prescribed by a doctor.

In Case of Overdose

• Symptoms: Hearing loss, dizziness, kidney injury, muscle weakness, difficulty breathing.

• Management: Stop drug immediately, provide supportive therapy, monitor renal and auditory function, dialysis may be required in severe cases.

Missed Dose

• Take as soon as remembered, unless close to next scheduled dose.

• Do not double the dose.

• Consult doctor for further instructions.

How To Use

• Administered via intramuscular injection or slow intravenous infusion.

• Must be given by a healthcare professional.

• Monitor renal function and hearing regularly during treatment.

When Not to Use / Contraindications

• Hypersensitivity to amikacin or other aminoglycosides

• Pre-existing hearing or balance problems

• Severe kidney impairment (unless essential and adjusted)

• Pregnancy (unless benefits outweigh risks)

• Patients with neuromuscular disorders (e.g., myasthenia gravis)

Side Effects

Common:

• Pain or irritation at injection site

• Headache, nausea, fever

• Rash

Serious:

• Ototoxicity (hearing loss, ringing in ears, vertigo)

• Nephrotoxicity (kidney damage)

• Neuromuscular blockade (muscle weakness, paralysis)

• Severe allergic reactions (rare)

Precautions & Warnings

• Use with caution in elderly patients and those with impaired kidney function

• Regular monitoring of kidney function and hearing tests is necessary

• Avoid long-term use due to increased toxicity risk

• Dose adjustment required in renal impairment

• Do not use with other ototoxic or nephrotoxic medicines unless necessary

Drug Interactions

• Loop diuretics (e.g., furosemide, ethacrynic acid) → increased risk of hearing damage

• Other aminoglycosides (gentamicin, kanamycin, tobramycin) → additive toxicity

• Vancomycin, amphotericin B, cisplatin, cyclosporine → increased risk of kidney damage

• Neuromuscular blockers → enhanced paralysis risk

Storage / Disposal

• Store below 25°C, in a cool dry place

• Protect from light and moisture

• Do not freeze

• Use immediately after opening/reconstitution

• Dispose of unused vials safely as per medical guidelines

Control Drug / Prescription Status

• Prescription-only medicine

Quick Tips

• Complete the full antibiotic course as prescribed

• Stay hydrated to protect kidneys

• Report immediately if you notice hearing problems or reduced urination

• Never self-inject — always get it administered by a healthcare professional