Leflox (500mg/100ml) IV Infusion – Levofloxacin Injection | 1 Vial

Description

Leflox Infusion contains Levofloxacin, a broad-spectrum fluoroquinolone antibiotic. It works by inhibiting bacterial DNA replication, effectively killing a wide range of gram-positive and gram-negative bacteria. Leflox is commonly prescribed for respiratory tract infections, urinary tract infections, skin infections, intra-abdominal infections, and septicemia when oral therapy is not suitable.

Ingredients

• Active Ingredient: Levofloxacin 500mg

• Excipients: Sodium chloride, water for injection, stabilizers

Drug Class

• Fluoroquinolone Antibiotic

Dosage Form

• Intravenous (IV) Infusion

• Strength: 500mg/100ml

• Single-use vial

Uses / Indications

• Community-acquired & hospital-acquired pneumonia

• Urinary tract infections (including pyelonephritis)

• Skin and soft tissue infections

• Intra-abdominal infections (with other agents)

• Prostatitis

• Septicemia and bacteremia

• Alternative for patients unable to tolerate oral levofloxacin

Dosage

💉 Adult Dose (IV Infusion):

• 500mg once or twice daily depending on infection type and severity

• Infusion time: at least 60 minutes per 500mg dose

📌 Duration of therapy usually 7–14 days, depending on infection.
Dose adjustments needed in renal impairment.

In Case of Overdose

• Symptoms: Confusion, dizziness, seizures, nausea, cardiac arrhythmias

• Management: Supportive treatment, ECG monitoring, maintain hydration

• Hemodialysis is not effective in removing levofloxacin

Missed Dose

• Administer as soon as remembered if within a short time

• If close to the next scheduled dose, skip the missed one

• Do not double the dose

How To Use

• Administer via slow IV infusion (over 60 minutes)

• Do not administer as rapid IV injection or intramuscularly

• Ensure patient hydration during therapy

• Dosage and duration determined by doctor based on infection type

When Not to Use / Contraindications

• History of hypersensitivity to levofloxacin or other quinolones

• Patients with tendon disorders related to fluoroquinolone use

• Children, adolescents, pregnant or breastfeeding women (risk of joint/tendon toxicity)

• Patients with known epilepsy or CNS disorders predisposing to seizures

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Headache, dizziness

• Injection site reactions

Serious:

• Tendonitis and tendon rupture

• QT prolongation, arrhythmias

• Central nervous system effects (seizures, tremors, psychosis)

• Severe allergic reactions (anaphylaxis, Stevens-Johnson syndrome)

• Clostridium difficile-associated diarrhea

Precautions & Warnings

• Avoid sun exposure (risk of photosensitivity)

• Use with caution in patients with cardiac disease (QT prolongation risk)

• Monitor renal function and adjust dose in renal impairment

• Risk of tendon rupture is higher in elderly and corticosteroid users

• Discontinue immediately if severe rash, tendon pain, or CNS symptoms occur

Drug Interactions

• Antacids, iron, zinc supplements: Reduce absorption

• NSAIDs: May increase seizure risk

• Warfarin: Increased anticoagulant effect (monitor INR)

• Antiarrhythmics, tricyclic antidepressants, macrolides: Risk of QT prolongation

• Corticosteroids: Increased risk of tendon rupture

Storage / Disposal

• Store below 25°C

• Protect from light and freezing

• Single-use vial – discard any unused portion safely

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not a controlled substance

Quick Tips

• Always complete the full course even if symptoms improve early

• Drink plenty of fluids during therapy

• Avoid driving or operating machinery if experiencing dizziness or confusion

• Report tendon pain, muscle weakness, or irregular heartbeat immediately

• Do not self-medicate – use only under doctor’s prescription