Description
Orno (8mg/2ml) Injection contains Ondansetron, a powerful antiemetic used to prevent and treat nausea and vomiting. It is commonly given to patients undergoing chemotherapy, radiotherapy, or surgery. The medicine works by blocking serotonin (5-HT3) receptors in the brain and gut, which trigger nausea and vomiting reflexes.
Ingredients
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Active Ingredient: Ondansetron (8mg/2ml)
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Inactive Ingredients: Sodium chloride, water for injection, and stabilizers
Drug Class
Dosage Form
Uses
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Prevention of chemotherapy-induced nausea and vomiting
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Prevention of nausea and vomiting after radiotherapy
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Management of post-operative nausea and vomiting
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Sometimes used in other severe nausea cases when oral therapy is not possible
Dosage
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Adults (Chemotherapy): 8mg IV/IM just before treatment, followed by additional doses as prescribed.
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Post-operative nausea: 4mg IV administered before or after surgery.
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Pediatric use: dose adjusted according to body weight and doctor’s instructions.
⚠️ Dosage must always be determined by a doctor.
In Case of Overdose
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Symptoms: Vision disturbances, constipation, severe hypotension, fainting.
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Emergency medical care required immediately.
Missed Dose
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If missed during hospital treatment, the healthcare provider will reschedule.
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Do not take a double dose.
How To Use
When Not to Use
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Known allergy to Ondansetron or similar medicines
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Patients with congenital long QT syndrome
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Severe liver disease (dose adjustment required)
Side Effects
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Common: Headache, dizziness, constipation, injection site pain
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Less common: Drowsiness, flushing, diarrhea
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Rare but serious: Irregular heartbeat, allergic reaction, low blood pressure
Precautions & Warnings
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Caution in patients with heart rhythm disorders or liver problems
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May cause QT prolongation (heart rhythm changes)
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Pregnant or breastfeeding women should use only under medical supervision
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Inform doctor if taking any other antiemetic drugs
Drug Interactions
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May interact with apomorphine (contraindicated)
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Can interact with SSRIs, SNRIs (risk of serotonin syndrome)
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Use caution with medicines affecting heart rhythm (e.g., amiodarone, quinidine)
Storage/Disposal
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Store below 30°C in a cool, dry place
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Protect from light and moisture
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Do not freeze
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Keep away from children
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Dispose of unused vials safely, per medical guidelines
Control Drug
Quick Tips
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Usually given in hospitals before chemotherapy, radiotherapy, or surgery
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May cause mild dizziness — avoid driving if affected
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Stay hydrated during treatment to reduce side effects
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Inform your doctor about any history of heart problems before starting