Provas (1g/100ml) IV Infusion – Tranexamic Acid for Bleeding Control

Description

Provas (1g/100ml) IV Infusion contains Tranexamic Acid, an antifibrinolytic agent that helps control and prevent excessive bleeding by stabilizing blood clots. It is commonly used in surgical procedures, trauma, heavy menstrual bleeding, postpartum hemorrhage, and other bleeding disorders where clot stabilization is required.

Ingredients

• Active Ingredient: Tranexamic Acid 1g (per 100ml infusion)

• Excipients: Sterile water, stabilizers, and buffers

Drug Class

• Antifibrinolytic Agent

• Hemostatic

Dosage Form

• Intravenous Infusion

• Strength: 1g/100ml per vial

Uses / Indications

• Control of bleeding in major surgeries (e.g., cardiac, liver, orthopedic)

• Management of trauma-related hemorrhage

• Treatment of postpartum hemorrhage

• Control of heavy menstrual bleeding (menorrhagia)

• Treatment and prevention of hereditary angioedema attacks

• Prevention of bleeding in hemophilia patients undergoing dental extractions

Dosage

💉 Typical Adult Dose (IV Infusion):

• 1g infused slowly IV over 10–20 minutes (not faster than 1ml/min)

• Repeat as needed depending on bleeding severity

• Maximum doses depend on patient’s condition and physician’s guidance

⚠️ Pediatric and elderly dosages should be adjusted under medical supervision.

In Case of Overdose

• Symptoms: Hypotension, dizziness, nausea, visual disturbances, seizures (rare)

• Management: Supportive care, airway maintenance, seizure control if required

Missed Dose

• In hospital, the healthcare team will adjust timing if a dose is missed.

• Do not double dose to make up for a missed infusion.

How To Use

• Administered only by a healthcare professional via IV infusion

• Infuse slowly to prevent hypotension or dizziness

• Duration and frequency depend on the severity and site of bleeding

When Not to Use / Contraindications

• Known hypersensitivity to tranexamic acid

• Patients with active intravascular clotting (DVT, PE, arterial thrombosis)

• History of seizures (use cautiously)

• Severe renal impairment without dosage adjustment

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Hypotension (if infused too rapidly)

• Headache, dizziness

Serious (rare):

• Seizures

• Vision changes (color perception disturbance)

• Thromboembolic events (deep vein thrombosis, pulmonary embolism, stroke)

Precautions & Warnings

• Use cautiously in patients with renal impairment – dose adjustment required

• Avoid in patients with a history of thrombosis or clotting disorders

• Monitor for visual disturbances during prolonged therapy

• Risk of seizures with high IV doses

• Not recommended for use in patients with subarachnoid hemorrhage due to risk of cerebral ischemia

Drug Interactions

• Estrogen-containing contraceptives → Increased risk of clot formation

• Anticoagulants (e.g., warfarin, heparin) → Antagonistic effects

• Tretinoin (oral, for APL treatment) → May increase risk of clotting

• Combination with other pro-coagulant agents increases thrombotic risk

Storage / Disposal

• Store below 25°C

• Protect from light and freezing

• Use immediately after opening; discard unused portion

• Dispose of according to hospital/medical waste guidelines

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not classified as a controlled drug

Quick Tips

• Always infused under hospital supervision

• Inform your doctor if you have a history of blood clots or seizures

• Report symptoms like sudden chest pain, leg swelling, or shortness of breath immediately

• Avoid alcohol and smoking, as these increase clotting risks

• Transition to oral tranexamic acid may be advised if longer treatment is needed