Description
Moduretic (5/50mg) Tablets combine two effective diuretics — Amiloride Hydrochloride and Hydrochlorothiazide — to treat high blood pressure (hypertension) and fluid retention (edema) caused by heart failure, liver cirrhosis, or kidney disorders.
This dual-action medicine helps your body remove excess salt and water while conserving potassium, maintaining electrolyte balance, and supporting healthy heart and kidney function.
Ingredients
Drug Class
Dosage Form
Uses
Moduretic Tablets are used for:
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Treatment of high blood pressure (hypertension)
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Management of edema (fluid retention) due to:
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Congestive heart failure
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Liver cirrhosis
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Kidney disorders
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Prevention of low potassium levels (hypokalemia) caused by other diuretics
Dosage
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Adults: Typically one tablet daily, with or without food.
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Dose may be adjusted by your doctor based on response and condition.
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Always follow your healthcare provider’s exact instructions.
In Case of Overdose
Symptoms may include:
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Severe dizziness
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Muscle weakness
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Irregular heartbeat
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Dehydration
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Electrolyte imbalance
Action: Seek immediate medical help or go to the nearest emergency facility.
Missed Dose
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Take the missed dose as soon as you remember.
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If it’s almost time for your next dose, skip the missed one.
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Do not double the dose to compensate.
How To Use
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Take Moduretic orally with water, preferably after a meal to reduce stomach upset.
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Take it at the same time each day.
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Avoid taking it late in the evening to prevent frequent nighttime urination.
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Continue taking it even if you feel well—hypertension often has no visible symptoms.
When Not to Use
Do not use Moduretic if you:
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Are allergic to Amiloride, Hydrochlorothiazide, or similar drugs
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Have high potassium levels (hyperkalemia)
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Suffer from severe kidney problems or anuria (no urine output)
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Have severe liver disease
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Are taking potassium supplements or other potassium-sparing diuretics
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Are pregnant or breastfeeding without medical advice
Side Effects
Common side effects:
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Nausea, vomiting, or stomach upset
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Headache
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Dizziness or light-headedness
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Muscle cramps
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Weakness
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Increased urination
Serious side effects:
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High potassium levels (irregular heartbeat, tingling sensation)
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Dehydration (dry mouth, extreme thirst)
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Allergic reactions (rash, swelling, difficulty breathing)
Seek medical attention if severe symptoms occur.
Precautions & Warnings
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Monitor kidney function and electrolytes regularly.
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Use cautiously if you have diabetes, gout, or kidney/liver disease.
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Avoid potassium supplements or salt substitutes unless directed by your doctor.
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May cause dizziness—avoid driving or operating machinery until you know how it affects you.
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Avoid alcohol—it can increase side effects like dizziness or dehydration.
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Pregnant or breastfeeding women should consult a physician before use.
Drug Interactions
Inform your doctor if you are taking:
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ACE inhibitors or ARBs (e.g., lisinopril, losartan)
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Potassium supplements or salt substitutes
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NSAIDs (e.g., ibuprofen)
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Lithium – may increase lithium toxicity
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Antidiabetic medications – blood sugar levels may fluctuate
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Other diuretics or corticosteroids – may alter electrolyte balance
Storage/Disposal
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Store below 30°C in a cool, dry place, away from sunlight and moisture.
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Keep out of reach of children.
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Dispose of unused tablets safely—do not flush or throw in household waste.
Control Drug
Quick Tips
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Take Moduretic early in the day to avoid nighttime urination.
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Stay hydrated, but avoid excessive fluid intake.
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Avoid salt substitutes and high-potassium foods (like bananas, oranges, or spinach) unless advised.
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Monitor blood pressure and potassium levels regularly.
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Continue medication even if you feel well—stopping suddenly may worsen your condition.
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Stand up slowly to reduce dizziness caused by sudden drops in blood pressure.
