Zestoretic (20/25mg) Tablets – Lisinopril + Hydrochlorothiazide | Dual Action Blood Pressure Control (28’s)

Description

Zestoretic (20/25mg) Tablets combine two proven blood pressure medicines — Lisinopril (20mg), an ACE inhibitor, and Hydrochlorothiazide (25mg), a thiazide diuretic — for effective, long-term control of high blood pressure (hypertension).
This dual-action formulation works by relaxing blood vessels and removing excess salt and water from the body, leading to lower blood pressure, reduced fluid retention, and a decreased workload on the heart.
Zestoretic helps prevent heart attacks, strokes, kidney disease, and other hypertension-related complications when used regularly as prescribed.

Ingredients

• Active Ingredients:

  • Lisinopril 20mg

  • Hydrochlorothiazide 25mg

• Inactive Ingredients: Lactose monohydrate, maize starch, magnesium stearate, calcium phosphate, and coating materials.

Drug Class

• Class: ACE Inhibitor (Lisinopril) + Thiazide Diuretic (Hydrochlorothiazide)

• Category: Antihypertensive Combination

Dosage Form

• Form: Film-coated tablet

• Packaging: 28 tablets per pack

Uses

Zestoretic (20/25mg) is indicated for:

• Treatment of essential hypertension (high blood pressure)

• Combination therapy when single-agent treatment is not effective

• Reducing risk of heart attack, stroke, or kidney failure

• Fluid retention (edema) management associated with hypertension

Dosage

• Adults:

  • Usual dose: 1 tablet (20/25mg) once daily.

  • Your doctor may adjust the dose depending on blood pressure response.

• Elderly or patients with kidney problems: Lower starting dose may be recommended.

• Route: Oral, swallow whole with a glass of water.

⚠️ Take your dose at the same time daily, preferably in the morning.

In Case of Overdose

Symptoms may include extreme dizziness, fainting, dehydration, electrolyte imbalance, or very low blood pressure.
➡️ Action: Seek immediate medical attention or go to the nearest emergency facility.

Missed Dose

If you miss a dose, take it as soon as you remember.
If it’s nearly time for your next dose, skip the missed one.
⚠️ Do not double up to make up for a missed tablet.

How To Use

• Take once daily, ideally in the morning to avoid nighttime urination.

• Can be taken with or without food.

• Swallow the tablet whole with water.

• Continue taking regularly, even if you feel well — high blood pressure often has no symptoms.

• Do not stop medication abruptly without consulting your doctor.

When Not to Use

Do not use Zestoretic if you:

• Are allergic to Lisinopril, Hydrochlorothiazide, or other ACE inhibitors.

• Have a history of angioedema (swelling of face, lips, or throat).

• Have severe kidney disease or are on dialysis.

• Are pregnant or breastfeeding.

• Have severe liver problems or are unable to urinate (anuria).

• Are taking aliskiren and have diabetes or kidney impairment.

Side Effects

Common side effects:

• Dizziness or lightheadedness

• Dry cough (due to Lisinopril)

• Headache or fatigue

• Increased urination

• Nausea, upset stomach

• Muscle cramps or weakness

Serious side effects (seek immediate medical help):

• Swelling of face, lips, or throat (angioedema)

• Severe dehydration or electrolyte imbalance

• Fainting or irregular heartbeat

• Signs of infection (fever, sore throat)

• Severe allergic reaction or rash

Precautions & Warnings

• Avoid during pregnancy and breastfeeding — may harm the baby.

• Use cautiously if you have diabetes, gout, or kidney/liver disease.

• Avoid alcohol — may increase dizziness or fainting risk.

• Monitor blood pressure, kidney function, and electrolyte levels regularly.

• Avoid potassium supplements or salt substitutes unless directed by your doctor.

• Rise slowly from sitting or lying positions to prevent dizziness.

• Inform your doctor about any persistent dry cough or facial swelling.

Drug Interactions

Zestoretic may interact with:

• Potassium supplements or potassium-sparing diuretics (e.g., spironolactone) – may cause high potassium.

• NSAIDs (e.g., ibuprofen, naproxen) – may reduce effectiveness.

• Lithium – increases risk of lithium toxicity.

• Other antihypertensives – may cause excessive BP lowering.

• Alcohol or sedatives – increase dizziness and fainting risk.

• Diabetic drugs or insulin – may need blood sugar monitoring.

Storage/Disposal

• Store below 30°C, away from sunlight and moisture.

• Keep out of reach of children.

• Do not use beyond expiry date.

• Dispose of unused or expired tablets safely — do not flush down the toilet.

Control Drug

• Not a controlled substance (Prescription-only medicine).

Quick Tips

💡 Quick Tips for Safe Use:

• Take your tablet at the same time each morning.

• Drink enough fluids unless advised otherwise by your doctor.

• Avoid salt substitutes containing potassium.

• Monitor your blood pressure and kidney function regularly.

• Continue taking even if you feel better — hypertension treatment is long-term.

• Do not stop medication suddenly; consult your doctor first.

• Report any swelling, dry cough, or unusual tiredness promptly.