Vorif (200mg) 10 Tablets

Vorif 200mg Tablets contain Voriconazole, a broad-spectrum antifungal medication used to treat serious fungal infections. It works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane, leading to the death of the fungus. Vorif is prescribed for infections caused by Aspergillus, Candida, and Scedosporium species, particularly in immunocompromised patients.

Ingredients

• Active Ingredient: Voriconazole 200mg

• Inactive Ingredients: Lactose monohydrate, microcrystalline cellulose, magnesium stearate, povidone, croscarmellose sodium, and other excipients.

Drug Class

• Antifungal (Triazole Class)

Dosage Form

• Oral Tablet

Uses
Vorif 200mg Tablets are used for:

• Invasive aspergillosis (lung and sinus fungal infections)

• Severe Candida infections, including candidemia

• Fungal infections in patients with weakened immune systems (e.g., HIV/AIDS, cancer, transplant)

• Fungal infections caused by Scedosporium and Fusarium species

• Secondary prophylaxis against fungal infections in high-risk patients

Dosage

• Adults:

  • Initial (loading) dose: 400mg every 12 hours for the first day

  • Maintenance dose: 200mg every 12 hours thereafter

• Children (2-12 years): Dose adjusted by body weight as directed by a doctor.

• Take at least one hour before or after meals for optimal absorption.

• Follow your doctor’s instructions carefully.

In Case of Overdose

• Symptoms: Visual disturbances, confusion, hallucinations, nausea, or abnormal liver function.

• Seek immediate medical attention or contact a poison control center.

Missed Dose

• Take the missed dose as soon as you remember.

• Skip the missed dose if it’s nearly time for your next scheduled one.

• Do not double doses.

How To Use

1. Take Vorif exactly as prescribed by your doctor.

2. Swallow the tablet whole with a full glass of water.

3. Take on an empty stomach—either one hour before or one hour after meals.

4. Continue the medication for the entire prescribed duration, even if you start to feel better.

When Not to Use
Do not use Vorif 200mg if you have:

• Allergy to Voriconazole or other azole antifungal agents.

• Concurrent use of medications that may cause serious interactions (like rifampicin, carbamazepine, or ergot alkaloids).

• Severe liver impairment unless closely monitored by a physician.

Side Effects
Common side effects:

• Visual disturbances (blurred vision, color changes)

• Nausea, vomiting, diarrhea

• Headache

• Rash

Less common or serious side effects:

• Elevated liver enzymes (hepatitis, jaundice)

• Sensitivity to sunlight (photosensitivity)

• Hallucinations or confusion

• Severe skin reactions (Stevens-Johnson syndrome)

Precautions & Warnings

• Avoid direct sunlight exposure; use sunscreen and protective clothing.

• Regularly monitor liver function during long-term use.

• Use with caution in patients with kidney or liver disease.

• Avoid alcohol as it may increase the risk of liver damage.

• Do not drive or operate machinery if you experience visual disturbances.

• Pregnant or breastfeeding women should use only if clearly needed and prescribed by a doctor.

Drug Interactions
Vorif interacts with several medications, including:

• Rifampicin, rifabutin, carbamazepine, phenobarbital: Decrease voriconazole effectiveness.

• Warfarin and anticoagulants: Increased bleeding risk.

• Cyclosporine, tacrolimus: Increased risk of toxicity.

• Phenytoin: Alters voriconazole levels.

• Statins and certain antihistamines: May cause serious side effects.
  Always inform your doctor about all medicines and supplements you are using.

Storage/Disposal

• Store below 30°C in a cool, dry place away from direct sunlight and moisture.

• Keep out of reach of children.

• Do not use after the expiry date printed on the package.

• Dispose of unused or expired medicine as per pharmacist instructions.

Control Drug
No – Not a controlled substance.

Quick Tips

• Take Vorif on an empty stomach for best absorption.

• Avoid exposure to direct sunlight; use sun protection.

• Report any vision changes or unusual skin reactions to your doctor immediately.

• Do not skip doses or stop early without consulting your physician.

• Keep up with regular blood and liver function tests during treatment.