Procarbizole (50mg) 100 Tablets

Procarbizole (50mg) is an anticancer (chemotherapy) medication used in the treatment of Hodgkin’s lymphoma and certain other types of cancers. It contains Procarbazine Hydrochloride, which works by interfering with the growth of cancer cells and preventing them from multiplying. This medicine is often used in combination with other chemotherapy agents as part of a treatment regimen to slow or stop the spread of cancerous cells.

Ingredients
Active Ingredient: Procarbazine Hydrochloride 50 mg
Inactive Ingredients: Lactose, magnesium stearate, microcrystalline cellulose, starch, and other excipients.

Drug Class
Antineoplastic (Alkylating Agent) / Cytotoxic Chemotherapy Drug

Dosage Form
Oral Tablet

Uses

• Treatment of Hodgkin’s lymphoma (as part of the MOPP regimen or similar chemotherapy combinations)

• Certain brain tumors (as directed by an oncologist)

• Some other malignancies as determined by a specialist

Dosage

• The dosage varies depending on body weight, treatment protocol, and medical condition.

• Typical adult starting dose: 2–4 mg/kg daily in divided doses, adjusted according to response and tolerance.

• Must be taken strictly under medical supervision.

• Always follow the oncologist’s prescribed schedule and dosage instructions carefully.

In case of Overdose
Symptoms may include nausea, vomiting, dizziness, tremors, or mental confusion. Overdose can cause severe bone marrow suppression. Seek immediate medical attention or contact your oncologist if an overdose is suspected.

Missed Dose
If you miss a dose, contact your doctor or treatment center for advice. Do not double the dose or take extra tablets unless specifically directed by your doctor.

How To Use
Take the tablet orally with or after meals, as directed by your physician.
Swallow whole with a full glass of water—do not crush or chew.
Avoid alcohol, fermented foods, and tyramine-rich foods (such as aged cheese, smoked meat, and certain wines), as Procarbizole may interact with them.
Maintain regular follow-ups for blood counts and medical monitoring.

When Not to Use

• If allergic to Procarbazine or any of its components

• During pregnancy or breastfeeding

• If you have severe bone marrow suppression or blood disorders

• In patients with uncontrolled infections

• If taking medications that interact with monoamine oxidase inhibitors (MAOIs)

Side Effects
Common: Nausea, vomiting, loss of appetite, tiredness, and mild dizziness
Less common: Constipation, headache, dry mouth, or rash
Serious (rare): Bone marrow suppression (low white blood cell count, anemia, or low platelets), liver toxicity, confusion, tremors, seizures, or allergic reactions

Precautions & Warnings

• Use only under the supervision of an oncologist.

• Regular blood tests are required to monitor blood cell counts and liver function.

• Avoid alcohol and tyramine-rich foods to prevent dangerous interactions (can cause high blood pressure and severe reactions).

• Avoid pregnancy during treatment and for several months after stopping—can cause birth defects.

• Avoid live vaccines during and after therapy.

• Inform your doctor if you experience signs of infection, bleeding, or unusual fatigue.

Drug Interactions

• Alcohol – may cause severe reactions (flushing, nausea, vomiting).

• MAO inhibitors or antidepressants – dangerous interaction risk.

• Sedatives or CNS depressants – increased drowsiness or confusion.

• Other chemotherapy or immunosuppressive drugs – may enhance bone marrow suppression.

• Tyramine-rich foods (aged cheese, cured meats, soy products, wine) – may trigger hypertensive crisis.

Storage/Disposal
Store below 25°C in a cool, dry place, away from light and moisture.
Keep out of reach of children.
Do not use after expiry date. Dispose of unused medicine safely according to local guidelines—do not flush down the drain.

Control Drug
Prescription-only medicine. Not a controlled drug.

Quick Tips

• Take under strict medical supervision.

• Avoid alcohol and tyramine-containing foods.

• Report any fever, sore throat, or bleeding to your doctor immediately.

• Maintain good hygiene to reduce infection risk.

• Do not miss regular blood tests during treatment.

• Use effective birth control during and after therapy as advised.