Description
Clexane contains Enoxaparin Sodium, a low molecular weight heparin (LMWH) used as an anticoagulant (blood thinner). It helps prevent the formation of harmful blood clots in veins, arteries, or lungs. Clexane is commonly prescribed for the prevention and treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and clotting disorders after surgery. It is also used in patients with unstable angina or heart attack to improve blood flow and reduce complications.
Ingredients
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Active Ingredient: Enoxaparin Sodium 40mg (per 0.4ml)
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Inactive Ingredients: Water for injection, hydrochloric acid/sodium hydroxide (pH adjustment)
Drug Class
Anticoagulant (Low Molecular Weight Heparin)
Dosage Form
Pre-filled syringe injection (subcutaneous use) – 2 × 0.4ml syringes (40mg)
Uses
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Prevention of deep vein thrombosis (DVT) after surgery or long bed rest
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Treatment of pulmonary embolism (PE)
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Prevention of clotting in patients with restricted mobility
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Management of unstable angina and non-ST elevation myocardial infarction (NSTEMI)
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Used in some cases during hemodialysis to prevent clotting in dialysis lines
Dosage
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Adults (Prophylaxis): 40mg once daily via subcutaneous injection
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Treatment of DVT/PE: 1mg/kg body weight every 12 hours or 1.5mg/kg once daily
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Dosage may vary based on kidney function, weight, and medical condition
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Always follow the exact dose prescribed by your doctor
In Case of Overdose
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Symptoms: Excessive bleeding, unusual bruising, blood in urine/stool, prolonged clotting time
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Management: Immediate medical attention; protamine sulfate may be used as an antidote
Missed Dose
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Take as soon as you remember, unless it is almost time for your next dose
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Do not double the dose to make up for the missed injection
How to Use
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For subcutaneous injection only (do not inject into muscle or vein unless instructed)
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Usually administered in the abdomen (stomach area), alternating sides
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Do not expel air bubble from the syringe before injection (it helps prevent leakage)
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Use under medical supervision or with proper training
When Not to Use
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Allergy to Enoxaparin, Heparin, or other anticoagulants
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Active major bleeding or conditions with high bleeding risk
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History of heparin-induced thrombocytopenia (HIT)
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Severe uncontrolled hypertension
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Patients with active stomach or intestinal ulcers
Side Effects
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Common: Pain, redness, or bruising at injection site
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Serious (Seek help): Unusual bleeding, black/tarry stools, blood in urine, severe headache, dizziness, or chest pain
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Rare: Allergic reactions (rash, itching, swelling, breathing difficulty)
Precautions & Warnings
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Use with caution in patients with kidney disease, liver problems, or low platelet count
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Inform doctor if you are pregnant or breastfeeding
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Regular blood clotting tests (platelet count, anti-Xa levels) may be required
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Avoid activities that increase bleeding risk (contact sports, sharp tools)
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Inform healthcare providers before surgery or dental procedures
Drug Interactions
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Other anticoagulants (Warfarin, Dabigatran, Rivaroxaban)
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Antiplatelets (Aspirin, Clopidogrel)
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NSAIDs (Ibuprofen, Diclofenac, Naproxen)
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Herbal supplements with blood-thinning effects (Garlic, Ginkgo, Ginger)
Storage/Disposal
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Store below 25°C, away from heat and direct light
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Do not freeze
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Keep out of reach of children
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Dispose of syringes in a puncture-proof sharps container
Control Drug
Yes – Clexane is a prescription-only anticoagulant and must be used under medical supervision.
Quick Tips
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Do not self-inject unless trained by a healthcare professional
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Rotate injection sites to reduce bruising and pain
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Report any unusual bleeding immediately
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Avoid over-the-counter painkillers without doctor’s approval
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Never stop using suddenly without consulting your doctor, as it may increase clot risk
