Depo-Medrol (80mg/2ml) Injection – Methylprednisolone Acetate | 1 Ampoule

Description

Depo-Medrol Injection (Methylprednisolone Acetate 80mg/2ml) is a long-acting corticosteroid used to reduce inflammation and suppress immune responses in a variety of medical conditions. It provides relief in allergic reactions, joint pain, arthritis, respiratory conditions, and certain autoimmune disorders. It is administered intramuscularly or intra-articularly by a healthcare professional.

Ingredients

• Active Ingredient: Methylprednisolone Acetate 80mg

• Excipients: Polyethylene glycol, myristyl-gamma-picolinium chloride, sodium chloride, sterile water for injection

Drug Class

• Corticosteroid (Glucocorticoid)

Dosage Form

• Injection (Suspension for IM or intra-articular use)

• Strength: 80mg/2ml per ampoule

Uses / Indications

• Rheumatoid arthritis & osteoarthritis (intra-articular)

• Bursitis & tendinitis

• Severe allergic conditions (asthma, hay fever, drug reactions)

• Autoimmune diseases (systemic lupus erythematosus, dermatomyositis)

• Skin disorders (severe psoriasis, dermatitis)

• Endocrine disorders (adrenal insufficiency, congenital adrenal hyperplasia)

• Certain respiratory conditions (chronic obstructive pulmonary disease, severe asthma)

Dosage

💉 To be administered by healthcare professionals only

• Adults:

  • Dose depends on condition and route of administration

  • Intramuscular: Usually 40–120mg every 1–4 weeks

  • Intra-articular: 20–80mg depending on joint size

• Children: Dose individualized based on weight and disease severity

In Case of Overdose

• Symptoms: Cushing’s syndrome features, increased blood sugar, fluid retention, hypertension

• Treatment: Supportive care, monitor electrolyte and fluid balance

Missed Dose

• If a scheduled injection is missed, contact your doctor

• Do not self-administer extra doses

How To Use

• Administered intramuscularly, intra-articularly, intralesionally, or into soft tissues depending on condition

• Must be given by a trained medical professional

• Do not inject intravenously

When Not to Use / Contraindications

• Hypersensitivity to methylprednisolone or any component

• Systemic fungal infections

• Intrathecal or intravenous administration (contraindicated)

• Caution in patients with tuberculosis, peptic ulcer disease, or uncontrolled diabetes

Side Effects

Common:

• Pain or irritation at injection site

• Headache, dizziness

• Increased appetite, weight gain

• Mood changes (anxiety, restlessness)

Serious (seek medical help):

• Severe infections due to suppressed immunity

• Stomach ulcers, bleeding

• High blood pressure, fluid retention

• Osteoporosis with long-term use

• Visual disturbances (glaucoma, cataracts)

• Cushingoid features (moon face, fat redistribution)

Precautions & Warnings

• Long-term use may cause osteoporosis, adrenal suppression, and immunosuppression

• Monitor blood sugar in diabetic patients

• Use with caution in patients with hypertension, kidney, or liver disease

• Avoid abrupt discontinuation after prolonged therapy — taper dose gradually

• Not recommended during pregnancy unless necessary; may pass into breast milk

Drug Interactions

• NSAIDs (↑ risk of ulcers/bleeding)

• Anticoagulants (may alter INR)

• Vaccines (↓ immune response, ↑ risk of infection)

• Cyclosporine (↑ risk of seizures)

• Antidiabetic medications (reduced effectiveness)

• Rifampin, phenytoin (reduce corticosteroid effect)

Storage / Disposal

• Store below 25°C, protect from light

• Do not freeze

• Shake well before use (suspension)

• Discard unused portion safely as per medical waste guidelines

Control Drug / Prescription Status

• Prescription-only medicine

Quick Tips

• Depo-Medrol is not a painkiller, but works by reducing inflammation

• Always receive the injection under medical supervision

• Inform your doctor about long-term corticosteroid use before surgery

• Avoid close contact with people having infections like chickenpox or measles

• Do not stop treatment suddenly — tapering is required to prevent adrenal crisis