Genticyn 80 mg / 2 mL (Gentamicin Sulfate) — 2 Ampoules | IV/IM Antibiotic

Description

Genticyn injection is a sterile solution of gentamicin sulfate equivalent to 80 mg gentamicin base in 2 mL (40 mg/mL). It is intended for intramuscular (IM) or intravenous (IV) administration for treatment of serious bacterial infections caused by susceptible organisms. 

Ingredients

• Active ingredient: Gentamicin sulfate (equivalent to 80 mg gentamicin base per 2 mL ampoule).

• Other ingredients/excipients: typically water for injection and may include small amounts of sulfuric acid or pH adjusters depending on manufacturer — consult the specific product leaflet for full excipient list.

Drug Class

• Aminoglycoside antibiotic (bactericidal; primarily active against aerobic gram-negative bacilli and used in severe infections and synergy regimens). 

Dosage Form

• Single-use sterile ampoule: 2 mL solution (40 mg/mL). Sold here as a box of 2 ampoules (verify pack size/brand on supplier invoice). 

Uses / Indications

Used to treat infections caused by gentamicin-sensitive organisms, including:

• Severe gram-negative infections (e.g., Pseudomonas, Enterobacteriaceae)

• Septicaemia / bacteremia

• Complicated urinary tract infections

• Hospital-acquired pneumonia (in combination when indicated)

• Intra-abdominal and gynecologic infections (often used in combination therapy)

• Endocarditis (synergy with β-lactams for some organisms)
  Indications vary by local guidelines — culture & sensitivity should guide therapy. 

Dosage (Typical) — Clinical guidance only; follow prescriber orders

Conventional (multiple daily) dosing

• Typical adult dosing: 1–2 mg/kg every 8 hours (total ~3–6 mg/kg/day), adjusted for severity and renal function. Therapeutic drug monitoring (peak/trough) is required to minimize toxicity. 

Once-daily (extended-interval) dosing

• Many centres use once-daily regimens (e.g., 5–7 or up to 8–10 mg/kg once daily) depending on infection, patient factors and local policy — extended-interval dosing optimizes peak/MIC ratio and may reduce nephrotoxicity but requires appropriate selection and monitoring.

Special populations / renal impairment

• Dose and/or dosing interval must be adjusted in renal impairment (use creatinine clearance to guide interval extension or therapeutic drug monitoring). Pediatrics and neonates have distinct dosing — follow pediatric references. 

Practical note for a 70 kg adult: a common once-daily dose might be 5–7 mg/kg → 350–490 mg total daily (so multiple 80 mg ampoules or alternate products/vials will be used to reach the prescribed dose). Always follow the prescriber's exact order. 

In Case of Overdose

• Signs: worsening nephrotoxicity, ototoxicity (tinnitus, hearing loss, vertigo), neuromuscular blockade (respiratory depression).

• Management: stop drug, provide supportive care, monitor renal function, consider hemodialysis for clearance in severe cases (gentamicin is dialyzable to some extent); consult toxicology/poison control.

Missed Dose

• Genticyn is normally administered by healthcare staff. If a scheduled dose is missed, give it as soon as possible unless the next dose time is near — do not double doses. Follow prescriber/hospital protocol.

How to Use / Administration Instructions

• Inspect ampoule: solution should be clear to pale yellow; do not use if discolored or contains particulate matter. 

• IM administration: inject deep into a large muscle (e.g., gluteal) using aseptic technique. Rotate sites to reduce irritation.

• IV administration: give IV injection or infusion per local policy (some preparations diluted in compatible saline and infused slowly). Flush IV lines before/after administration.

• Monitoring: obtain baseline and periodic renal function (serum creatinine), and drug levels (peak/trough) when using conventional dosing or in at-risk patients. Monitor hearing/vestibular function for symptoms. 

When Not to Use / Contraindications

• Known hypersensitivity to gentamicin or other aminoglycosides.

• Use with extreme caution or avoid in patients with preexisting hearing impairment, myasthenia gravis or neuromuscular disorders (risk of neuromuscular blockade).

• Avoid unnecessary use in mild infections or when effective, less-toxic alternatives exist. 

Side Effects / Adverse Reactions

Major (clinically important)

• Nephrotoxicity (acute tubular necrosis risk; reversible if detected early) — monitor renal function.

• Ototoxicity (vestibular and/or cochlear; may be irreversible) — monitor for tinnitus, hearing loss, vertigo. Concomitant ototoxic drugs (e.g., loop diuretics, vancomycin) increase risk.

Other

• Neuromuscular blockade (rare but potentially life-threatening, especially with concurrent neuromuscular blockers), rash, injection-site pain. Superinfection (including C. difficile) can occur with broad antibiotic use.

Precautions & Warnings

• Therapeutic drug monitoring is recommended for conventional dosing, renal impairment, prolonged therapy, neonates, obese patients, and when toxicity risk is high. 

• Use caution or avoid concomitant nephrotoxic/ototoxic agents (e.g., vancomycin, amphotericin B, loop diuretics); monitor closely if combination is unavoidable. 

• Pregnant/breastfeeding: use only if clearly needed and benefits outweigh risks. Monitor neonates if mother received gentamicin near delivery. 

Drug Interactions

• Loop diuretics (e.g., furosemide): increased risk of ototoxicity.

• Vancomycin and other nephrotoxins: increased nephrotoxicity risk.

• Neuromuscular blocking agents: additive neuromuscular blockade.

• Other antibiotics: synergy possible with β-lactams against some organisms, but dosing and monitoring must be physician-directed. 

Storage / Disposal

• Storage: store at controlled room temperature (approx. 20–25 °C / 68–77 °F) unless product leaflet specifies otherwise. Protect from excessive heat. Do not freeze. 

• Disposal: single-use ampoules — discard any unused portion. Dispose of ampoules and sharps in approved biomedical waste / sharps containers per local regulations.

Control Drug / Prescription Status

• Prescription only. Genticyn must be prescribed and administered by or under the supervision of a licensed healthcare professional. Hospital/clinic administration is typical.

Quick Tips (for your Shopify page)

• Headline: Genticyn — Gentamicin Sulfate 80 mg / 2 mL (2 ampoules) — IV/IM antibiotic (Prescription only).

• Key bullets: 80 mg per ampoule (40 mg/mL); For serious gram-negative infections; Requires prescriber order and monitoring; Not for oral use; Store at room temperature.

• Safety callout (bold): Monitor renal function and hearing — risk of kidney damage and hearing loss; do not use without medical supervision.

• Sell note: Include a short downloadable PDF “Important Safety & Administration Notes” for clinicians/customers to print after purchase (contains dosing reminders, monitoring checklist, contraindications, and emergency contact).