Grasil 25 mg / 1 ml Injection – Box of 5 Ampoules (Amikacin Antibiotic)

Description

Grasil injection is a brand form of amikacin (an aminoglycoside antibiotic). It is used to treat serious bacterial infections caused by organisms susceptible to amikacin. The 1 ml ampoule delivers 25 mg of amikacin. The injectable formulation ensures rapid and direct systemic availability. 

Ingredients

• Active ingredient: Amikacin sulfate equivalent to 25 mg per 1 ml ampoule 

• Excipients / inactives: Water for injection, stabilizers, buffers, etc. (as per manufacturer) 

Drug Class

Aminoglycoside antibiotic (bactericidal, concentration-dependent) 

Dosage Form

Sterile injectable solution — 1 ml ampoule containing 25 mg amikacin 

Uses (Indications)

Grasil (amikacin) is indicated for serious infections caused by Gram-negative bacteria or those resistant to other antibiotics, such as:

• Bacteremia / sepsis

• Lower respiratory tract infections

• Intra-abdominal infections

• Urinary tract infections

• Bone and joint infections

• Skin & soft tissue infections

• Postoperative infections

• Others where a potent aminoglycoside is needed 

Dosage

• The dose for amikacin is typically calculated based on patient weight and renal function. 

• A commonly used regimen is 15 mg/kg per day, divided into multiple doses or sometimes once daily, depending on severity and pharmacokinetics. 

• In your product case (25 mg per 1 ml ampoule), multiple ampoules might be used to reach the needed dose depending on weight, under medical guidance.

• Dose adjustments in renal impairment are critical. 

In Case of Overdose

• Potential symptoms: hearing damage (ototoxicity), kidney damage (nephrotoxicity), neuromuscular blockade (weakness), vestibular toxicity (dizziness) 

• Treatment: supportive care, stopping the drug, monitoring kidney function, hearing tests, hydration, monitoring of electrolytes.

Missed Dose

• In clinical settings, missing a dose must be evaluated by the treating physician.

• Do not double up the next dose to compensate.

How To Use / Administration

• Administer intravenous (IV) or intramuscular (IM) routes. 

• For IV, infusion over 30–60 minutes is common to reduce toxicity risk. 

• Use aseptic technique.

• Monitor patient during and after administration (renal function, hearing, balance, vital signs).

When Not to Use (Contraindications)

• Known hypersensitivity or allergic reaction to amikacin or aminoglycosides

• Pre-existing hearing loss or vestibular dysfunction

• Severe renal impairment (unless dose adjustment)

• Myasthenia gravis or neuromuscular diseases (risk of neuromuscular blockade)

• Pregnancy and lactation: use only if benefits outweigh risks (aminoglycosides can cross placenta)

• Use with caution in the elderly

Side Effects

Common / less serious:

• Nausea, vomiting

• Loss of appetite

• Dizziness

• Injection site reactions

• Headache

• Mild renal function changes

Serious / toxic:

• Ototoxicity (hearing loss, tinnitus, vestibular damage) 

• Nephrotoxicity (renal damage) 

• Neuromuscular blockade, especially in susceptible individuals

• Allergic reactions (rash, anaphylaxis)

Precautions & Warnings

• Regularly monitor renal function (serum creatinine, BUN) 

• Monitor auditory and vestibular function (hearing tests) 

• Hydration is important to reduce nephrotoxicity

• Avoid use with other nephrotoxic or ototoxic drugs

• Use the lowest effective dose for shortest duration

• Inform surgical / dental teams of amikacin use

Drug Interactions

• Concurrent use of other nephrotoxic agents (e.g., aminoglycosides, vancomycin, cisplatin, loop diuretics) increases kidney risk 

• Other ototoxic drugs (e.g., loop diuretics) may add hearing risk

• Neuromuscular blocking agents (e.g., suxamethonium, tubocurarine) may have additive effects on muscle weakness

Storage / Disposal

• Store at controlled room temperature, below recommended maximum (often ≤ 25–30 °C) 

• Protect from light, moisture

• Do not freeze

• Use before expiry

• Dispose unused/expired ampoules safely as medical waste

Control Drug Status

• Amikacin is not a narcotic or controlled drug but is a prescription-only antibiotic, requiring medical oversight

Quick Tips

• Always adjust dose for renal function

• Use slow infusion to minimize toxicity

• Monitor hearing and kidney parameters during therapy

• Avoid combining with other harmful drugs

• Use minimal effective duration

• Inform patients of signs of hearing loss or dizziness