Humalog Mix-50 KwikPen (100 IU/ml) – 3ml Pre-Filled Pen, Pack of 5

Description

Humalog Mix-50 is a premixed human insulin analog containing 50% insulin lispro (rapid-acting) and 50% insulin lispro protamine suspension (intermediate-acting). It provides both rapid onset and intermediate duration of action, making it suitable for mealtime glucose control and basal coverage. Supplied in a KwikPen pre-filled device for convenient, accurate subcutaneous injection.

Ingredients

• Active Ingredients:

  • Insulin lispro (soluble, rapid-acting) – 50%

  • Insulin lispro protamine (suspension, intermediate-acting) – 50%

• Excipients: Zinc oxide, glycerol, phenol, m-cresol, protamine sulfate, dibasic sodium phosphate, water for injection, etc.

Drug Class

• Antidiabetic agent

• Insulin analog combination (biphasic insulin lispro)

Dosage Form

• Pre-filled KwikPen injection device

• Strength: 100 IU/ml

• Each pen contains 3 ml (300 IU insulin)

• Pack: 5 pens (total 1500 IU insulin)

Uses / Indications

• Treatment of Type 1 diabetes mellitus

• Treatment of Type 2 diabetes mellitus when oral agents are insufficient

• Provides both prandial (mealtime) and basal insulin coverage in a single injection

Dosage

• Individualized according to patient’s blood glucose, diet, activity, and medical advice

• Usually injected within 15 minutes before a meal

• May be administered once or multiple times daily depending on regimen

• Total daily insulin requirement generally 0.5 – 1.0 IU/kg body weight/day (combined with other insulins if needed)

• Dose adjustments required during illness, stress, surgery, or pregnancy

In Case of Overdose

• Main risk: severe hypoglycemia (sweating, tremor, hunger, palpitations, confusion, seizures, unconsciousness)

• Management:

  • Mild: consume fast-acting carbohydrates (glucose tablets, fruit juice)

  • Severe: require glucagon injection or IV glucose in a medical setting

• Continuous monitoring is essential until stable

Missed Dose

• If missed and close to mealtime, inject as soon as possible

• If next scheduled dose is near, skip missed dose and resume as normal

• Never double the next dose to compensate

How To Use / Administration Instructions

1. Wash hands and prepare injection site (abdomen, thigh, upper arm, or buttock).

2. Prime the pen as per manufacturer’s instructions.

3. Dial the prescribed dose.

4. Inject subcutaneously; do not inject intramuscularly or intravenously.

5. Rotate injection sites to prevent lipodystrophy.

6. Store the pen in use at room temperature; do not refrigerate once opened.

When Not to Use / Contraindications

• During episodes of hypoglycemia

• Known hypersensitivity to insulin lispro or any excipients

• Not for intravenous use

Side Effects / Adverse Reactions

Common:

• Hypoglycemia

• Injection site reactions (pain, redness, swelling, itching)

Less common:

• Lipodystrophy (lipoatrophy or lipohypertrophy)

• Allergic skin reactions

• Edema (fluid retention)

Rare but serious:

• Systemic allergy/anaphylaxis

• Severe hypoglycemia leading to coma or seizures

Precautions & Warnings

• Monitor blood glucose regularly

• Adjust dose with changes in diet, activity, or illness

• Use with caution in patients with renal or hepatic impairment

• Insulin requirements may change during pregnancy and lactation

• Carry glucose source at all times to treat hypoglycemia

• Alcohol may enhance risk of hypoglycemia

Drug Interactions

• Increase hypoglycemic effect: oral antidiabetic drugs, ACE inhibitors, beta-blockers, salicylates, sulfonamides, alcohol

• Decrease effect (raise glucose): corticosteroids, oral contraceptives, thyroid hormones, diuretics, sympathomimetics

• Beta-blockers: may mask symptoms of hypoglycemia (except sweating)

Storage / Disposal

• Store unopened pens in refrigerator (2°C – 8°C); do not freeze

• Once in use, store at room temperature (<30°C) for up to 28 days

• Protect from heat and direct light

• Dispose of pens and needles in appropriate sharps container

Control Drug / Prescription Status

• Prescription-only medicine

• Must be used under healthcare professional supervision

Quick Tips

• Take Humalog Mix-50 15 minutes before meals

• Always check the insulin label and appearance before injection (should look cloudy/milky after gentle mixing)

• Do not reuse needles or share pens

• Maintain a blood glucose diary

• Keep emergency sugar/glucose tablets handy

• Educate family on use of glucagon injection in case of severe hypoglycemia