Description
Hyzonate 500mg Injection contains Hydrocortisone Sodium Succinate, a corticosteroid used for the treatment of severe inflammatory conditions, allergic reactions, adrenal insufficiency, and certain autoimmune disorders. It works by reducing inflammation, suppressing the immune system, and balancing natural steroid hormones in the body. Hyzonate is often used in emergency settings such as severe asthma attacks, anaphylaxis, or shock.
Ingredients
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Active Ingredient: Hydrocortisone Sodium Succinate 500mg
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Inactive Ingredients: Sodium phosphate buffers, sterile water for injection (may vary by manufacturer)
Drug Class
Corticosteroid (Glucocorticoid)
Dosage Form
Uses
Hyzonate 500mg is prescribed for:
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Severe allergic reactions (anaphylaxis)
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Asthma attacks and severe bronchospasm
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Rheumatic disorders (arthritis, lupus, etc.)
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Skin and eye diseases caused by inflammation
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Endocrine disorders (adrenal insufficiency, Addison’s disease)
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Shock due to trauma, surgery, or infections
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Autoimmune diseases (multiple sclerosis, ulcerative colitis, etc.)
Dosage
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Dosage is individualized based on condition, severity, and patient response
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Adults: Usually 100–500mg intravenously depending on the emergency and doctor’s instructions
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May be repeated every 2–6 hours as required
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Always administered under medical supervision
In Case of Overdose
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Symptoms: Swelling, high blood pressure, confusion, severe infections, electrolyte imbalance
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Management: Supportive treatment in hospital; electrolyte and cardiovascular monitoring required
Missed Dose
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Since Hyzonate is usually given in a hospital or under doctor’s supervision, missed doses are uncommon
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If self-administered, take the dose as soon as possible unless it’s almost time for the next one – do not double dose
How to Use
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Reconstitute the powder with provided diluent or as advised by healthcare professional
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Administer intravenously (IV) or intramuscularly (IM) only by trained personnel
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Never self-inject unless instructed by your doctor
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Dosage must be adjusted in stress conditions such as surgery, trauma, or infection
When Not to Use
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Allergy to Hydrocortisone or any corticosteroid
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Systemic fungal infections
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Patients receiving live or attenuated vaccines
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Untreated serious infections
Side Effects
Common:
Serious:
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High blood pressure, fluid retention
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Increased risk of infections
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Osteoporosis with long-term use
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Cushing’s syndrome (moon face, fat redistribution)
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Stomach ulcers, bleeding
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Adrenal suppression if stopped abruptly
Precautions & Warnings
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Use with caution in patients with diabetes, hypertension, peptic ulcers, infections, or osteoporosis
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Not recommended for long-term use without monitoring
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May mask signs of infection
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Dosage adjustments required in stress situations
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Pregnant and breastfeeding women should only use if clearly needed and prescribed
Drug Interactions
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NSAIDs (e.g., ibuprofen, aspirin) → risk of stomach bleeding
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Antidiabetic drugs → reduced effectiveness, may increase blood sugar
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Vaccines → may reduce vaccine effectiveness or increase risk of infection
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Antifungals, antibiotics, anticonvulsants → may alter hydrocortisone metabolism
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Diuretics → may increase risk of low potassium
Storage/Disposal
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Store at below 25°C in a cool, dry place
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Protect from light and moisture
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Use immediately after reconstitution
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Do not freeze
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Dispose of unused solution and vials in biomedical waste containers
Control Drug
Yes – Prescription-only medicine. Should only be used under doctor’s supervision.
Quick Tips
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Always complete the prescribed course unless told otherwise
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Do not stop treatment suddenly; tapering may be required
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Inform doctor if you have diabetes or hypertension before starting
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Carry a medical alert card if on long-term corticosteroid therapy
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Regular blood sugar and blood pressure monitoring is advised
