Kanacyn Injection 0.5g/2ml (Kanamycin Sulfate) — 1 Vial

Description

Kanacyn (0.5g/2ml) Injection contains Kanamycin sulfate, an aminoglycoside antibiotic used to treat severe bacterial infections. It is effective against gram-negative and certain gram-positive bacteria. It is often reserved for serious infections when other antibiotics are ineffective or contraindicated.

Ingredients

• Active Ingredient: Kanamycin Sulfate (500 mg per 2 ml vial)

• Excipients: Sterile water for injection and stabilizers (varies by manufacturer)

Drug Class

• Aminoglycoside Antibiotic

Dosage Form

• Injection (Intramuscular [IM] or Intravenous [IV])

Uses / Indications

• Severe bacterial infections caused by susceptible organisms

• Tuberculosis (in combination with other anti-TB drugs)

• Infections of the respiratory tract, urinary tract, gastrointestinal tract, bone, joints, and skin

• Septicemia, peritonitis, meningitis (as per specialist advice)

Dosage

⚠️ Dosage is individualized based on severity of infection, patient’s age, weight, and kidney function.

• Adults: Usually 15 mg/kg/day IM/IV in 2–3 divided doses (not exceeding 1.5 g/day).

• Children: 15–30 mg/kg/day in 2–3 divided doses.

• Tuberculosis (TB): 15 mg/kg IM once daily, often with other anti-TB agents.

In Case of Overdose

• Symptoms: Hearing loss, dizziness, kidney damage, muscle weakness, breathing difficulty.

• Management: Discontinue drug immediately, provide supportive treatment, monitor renal and auditory function, consider hemodialysis in severe toxicity.

Missed Dose

• Take the missed dose as soon as remembered.

• If it is close to the next scheduled dose, skip the missed dose.

• Do not double the dose to compensate.

How To Use

• Administered via intramuscular injection or slow intravenous infusion.

• Must be given by a healthcare professional only.

• Dosage must be adjusted in patients with kidney impairment.

When Not to Use / Contraindications

• Known hypersensitivity to kanamycin or other aminoglycosides

• Pre-existing hearing loss or vestibular dysfunction

• Severe renal impairment (unless benefits outweigh risks)

• During pregnancy (risk of fetal harm)

• Concurrent use with other ototoxic or nephrotoxic drugs (unless absolutely necessary)

Side Effects

Common:

• Injection site pain

• Nausea, vomiting

• Headache, fever

Serious:

• Ototoxicity (hearing loss, tinnitus, vertigo)

• Nephrotoxicity (kidney damage)

• Neuromuscular blockade (rare)

• Allergic reactions (rash, swelling, difficulty breathing)

Precautions & Warnings

• Monitor kidney function (serum creatinine, BUN) during treatment

• Regular hearing tests are recommended in long-term therapy

• Use cautiously in elderly patients and those with pre-existing renal impairment

• Avoid concurrent use with other aminoglycosides, vancomycin, amphotericin B, or loop diuretics (e.g., furosemide) due to increased toxicity

• Use with caution in neuromuscular disorders (e.g., myasthenia gravis)

Drug Interactions

• Other aminoglycosides (gentamicin, streptomycin) → increased ototoxicity/nephrotoxicity

• Loop diuretics (furosemide, ethacrynic acid) → enhanced hearing damage

• Amphotericin B, cyclosporine, cisplatin, vancomycin → higher risk of kidney injury

• Neuromuscular blockers → enhanced muscle paralysis

Storage / Disposal

• Store at room temperature (below 25°C)

• Protect from light and moisture

• Do not freeze

• Use reconstituted solution immediately or as per manufacturer’s guidance

• Safely discard unused or expired medicine following local regulations

Control Drug / Prescription Status

• Prescription-only medicine

• Must be used under strict medical supervision

Quick Tips

• Always complete the full prescribed course, even if you feel better

• Report hearing changes, ringing in the ears, or kidney problems immediately

• Stay well hydrated during treatment

• Not recommended for self-administration — only a healthcare professional should inject