Mofest (400mg/250ml) IV Infusion – Moxifloxacin Injection | 1 Vial

Description

Mofest IV Infusion contains Moxifloxacin, a broad-spectrum fourth-generation fluoroquinolone antibiotic. It works by inhibiting bacterial DNA replication, making it effective against both gram-positive and gram-negative bacteria, including drug-resistant strains. It is widely used in hospitals for respiratory, skin, intra-abdominal, and complicated infections when oral therapy is not possible.

Ingredients

• Active Ingredient: Moxifloxacin 400mg

• Excipients: Sodium chloride, water for injection, stabilizers

Drug Class

• Fluoroquinolone Antibiotic

Dosage Form

• Intravenous (IV) Infusion

• Strength: 400mg/250ml

• Single-use vial

Uses / Indications

• Community-acquired pneumonia

• Chronic bronchitis exacerbations

• Skin and soft tissue infections

• Intra-abdominal infections (in combination therapy)

• Complicated urinary tract infections

• When oral therapy is not suitable or patient is hospitalized

Dosage

💉 Adult Dose (IV Infusion):

• 400mg once daily via IV infusion

• Infusion time: 60 minutes minimum

• Duration: 5–14 days, depending on infection type

⚠️ Dose adjustment may be required in hepatic impairment.

In Case of Overdose

• Symptoms: QT prolongation, dizziness, nausea, seizures

• Management: Supportive care, ECG monitoring, hydration

• Hemodialysis not effective in eliminating moxifloxacin

Missed Dose

• Administer as soon as remembered if within a short time

• If next dose is near, skip missed dose

• Do not double the infusion dose

How To Use

• Administer via slow IV infusion over 60 minutes

• Do not give as rapid IV injection or IM injection

• Ensure proper hydration during treatment

• Must be prescribed and monitored by a healthcare professional

When Not to Use / Contraindications

• Hypersensitivity to moxifloxacin or other quinolones

• Patients with QT prolongation or cardiac arrhythmias

• Concurrent use with drugs prolonging QT interval

• Children, adolescents, pregnant or breastfeeding women (safety not established)

• Patients with severe hepatic impairment

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Headache, dizziness

• Injection site reactions

Serious:

• Tendonitis and tendon rupture

• QT prolongation → arrhythmias

• Central nervous system effects (confusion, seizures)

• Peripheral neuropathy

• Severe allergic reactions (anaphylaxis, Stevens-Johnson syndrome)

• Clostridium difficile-associated diarrhea

Precautions & Warnings

• Avoid sun exposure (photosensitivity risk)

• Use cautiously in elderly patients

• Monitor ECG in cardiac patients

• Stop treatment if tendon pain, severe rash, or CNS effects occur

• Adjust dose in liver dysfunction

Drug Interactions

• Antiarrhythmics, macrolides, tricyclic antidepressants: Increased QT prolongation risk

• NSAIDs: May increase seizure risk

• Antacids, iron, zinc supplements: Reduce absorption (avoid co-administration)

• Corticosteroids: Higher risk of tendon rupture

Storage / Disposal

• Store at below 25°C

• Protect from light and freezing

• Single-use vial – discard unused solution safely

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not a controlled substance

Quick Tips

• Always complete the full course even if symptoms improve early

• Drink plenty of water during therapy

• Avoid driving or operating machinery if dizziness occurs

• Inform your doctor about all ongoing medications before use

• Report tendon pain, irregular heartbeat, or severe rash immediately