Omega (40mg) IV Infusion – Omeprazole for Acid Control & Ulcer Treatment

Description

Omega (40mg) IV Infusion contains Omeprazole, a proton pump inhibitor (PPI) that reduces excess stomach acid production. It is widely used in the treatment of gastric ulcers, duodenal ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and prevention of stress ulcers in critically ill patients. The IV form provides rapid acid suppression in hospitalized patients who cannot take oral medication.

Ingredients

• Active Ingredient: Omeprazole 40mg

• Excipients: Stabilizers, buffers, sterile water (for infusion preparation)

Drug Class

• Proton Pump Inhibitor (PPI)

• Anti-ulcer agent

Dosage Form

• Intravenous Infusion (IV)

• Strength: 40mg per vial

Uses / Indications

• Treatment of gastric and duodenal ulcers

• Management of GERD and erosive esophagitis

• Prevention of upper GI bleeding in critically ill patients

• Zollinger-Ellison syndrome (acid hypersecretion disorder)

• Short-term treatment of NSAID-associated gastric ulcers

Dosage

💉 Typical Adult Dosage:

• 40mg once daily IV infusion (over 20–30 minutes)

• Severe reflux esophagitis: 40mg once daily

• Zollinger-Ellison syndrome: Dose adjusted according to acid output, sometimes >40mg/day

⚠️ Dosage should be individualized based on clinical condition and physician’s recommendation.

In Case of Overdose

• Symptoms: Confusion, drowsiness, tachycardia, flushing, headache, blurred vision

• Management: Supportive treatment, monitoring of vital signs. No specific antidote.

Missed Dose

• If a dose is missed in hospital, administer as soon as possible unless it is close to the next dose.

• Do not double dose.

How To Use

• To be administered by a healthcare professional only

• Reconstitute vial with suitable diluent before infusion

• Infuse slowly over recommended duration (not IV bolus unless indicated)

• For hospital/inpatient use where oral therapy is not feasible

When Not to Use / Contraindications

• Known allergy to omeprazole or other PPIs

• Patients taking rilpivirine-containing products (HIV therapy)

• Severe liver impairment (dose adjustment required)

Side Effects

Common:

• Headache

• Nausea, vomiting, abdominal pain

• Constipation or diarrhea

• Injection site irritation

Serious (rare):

• Low magnesium levels (muscle cramps, irregular heartbeat)

• Severe allergic reaction (rash, swelling, difficulty breathing)

• Clostridium difficile-associated diarrhea

• Vitamin B12 deficiency with long-term use

Precautions & Warnings

• Use cautiously in patients with hepatic impairment

• Long-term therapy may increase risk of osteoporosis-related fractures

• Monitor electrolytes in prolonged use (magnesium, calcium, potassium)

• May mask symptoms of gastric cancer – rule out malignancy before therapy

• Avoid unnecessary prolonged IV therapy; switch to oral route when possible

Drug Interactions

• Clopidogrel → May reduce antiplatelet effect

• Warfarin → Risk of increased INR and bleeding

• Phenytoin, diazepam, cyclosporine → Increased plasma levels possible

• Methotrexate (high dose) → Toxicity risk due to reduced clearance

Storage / Disposal

• Store below 25°C

• Protect from light and moisture

• Use immediately after reconstitution

• Dispose of unused solution safely according to hospital guidelines

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not a controlled drug

Quick Tips

• Used mainly in hospitals for patients unable to take oral medication

• Switch to oral omeprazole or another PPI as soon as the patient can tolerate

• Report persistent abdominal pain, black stools, or vomiting blood immediately

• Avoid alcohol and smoking to improve ulcer healing

• Do not self-administer at home without medical supervision