Rocephin (500mg) IV Injection | Broad-Spectrum Antibiotic for Severe Infections

Description

Rocephin (500mg) IV Injection contains Ceftriaxone Sodium, a third-generation cephalosporin antibiotic used for the treatment of a wide variety of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to the destruction of bacteria. Rocephin is highly effective against both Gram-positive and Gram-negative organisms and is commonly used in hospitals for moderate to severe infections.

Ingredients

• Active Ingredient: Ceftriaxone Sodium 500mg

• Inactive Ingredients: Sterile excipients suitable for IV administration

Drug Class

Antibiotic – Third-Generation Cephalosporin

Dosage Form

Injection – Powder for reconstitution (Intravenous)

Uses

Rocephin is indicated for the treatment of:

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Bone and joint infections

• Intra-abdominal infections

• Bacterial septicemia (blood poisoning)

• Meningitis (bacterial)

• Gonorrhea and pelvic inflammatory disease

• Surgical prophylaxis (to prevent post-surgical infections)

Dosage

• Adults & Children over 12 years: 1–2g once daily (or divided every 12 hours depending on severity).

• Severe Infections: Up to 4g daily in divided doses.

• Children (under 12 years): 20–80 mg/kg/day depending on infection.

• Always follow your doctor’s exact prescription.

In case of Overdose

• Symptoms: Seizures, confusion, kidney strain, gastrointestinal disturbances.

• Management: Supportive treatment with close monitoring of vital signs.

Missed Dose

• In hospital settings, doses are rarely missed.

• If missed, administer as soon as possible under medical supervision.

How To Use

• Reconstitute the vial with sterile water or suitable IV diluent.

• Administer slowly via intravenous infusion or injection by a healthcare professional.

• Do not self-administer.

• Complete the full course of therapy to prevent bacterial resistance.

When Not to Use

• Known allergy to ceftriaxone, cephalosporins, or penicillin derivatives.

• Neonates with hyperbilirubinemia (risk of kernicterus).

• Newborns requiring calcium IV therapy (risk of precipitation).

Side Effects

Common:

• Pain, swelling, or redness at injection site

• Diarrhea, nausea, or vomiting

• Mild rash or fever

Serious (rare):

• Severe allergic reactions (anaphylaxis)

• Pseudomembranous colitis (severe diarrhea)

• Gallbladder sludging

• Kidney dysfunction

• Blood-related disorders (anemia, low white blood cell count)

Precautions & Warnings

• Use with caution in patients with liver or kidney disease.

• Inform your doctor if you are pregnant or breastfeeding.

• Monitor for secondary infections during prolonged use.

• Avoid mixing with calcium-containing IV solutions (risk of precipitate formation).

Drug Interactions

May interact with:

• Calcium-containing IV fluids (e.g., Ringer’s, Hartmann’s)

• Aminoglycosides (may increase nephrotoxicity)

• Warfarin and other anticoagulants (increased bleeding risk)

• Loop diuretics (increased kidney strain)

Storage/Disposal

• Store below 25°C in a dry place.

• Protect from light and moisture.

• Use reconstituted solution immediately.

• Dispose of unused medicine and medical waste safely.

Control Drug

Prescription-only medicine (not a controlled substance).

Quick Tips

• Do not stop treatment early, even if you feel better.

• Report severe diarrhea or allergic reactions immediately.

• Inform your doctor about all previous antibiotic allergies.

• Drink plenty of fluids during treatment unless advised otherwise.