Rocephin 1g IV Injection – Broad-Spectrum Antibiotic | Ceftriaxone

Description

Rocephin (1g) IV Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic. It is given through intravenous (IV) infusion or injection and is commonly used in hospitals to treat severe bacterial infections. Rocephin works by inhibiting the growth of bacteria and is effective against a wide range of infections including respiratory, urinary, abdominal, skin, bone, and bloodstream infections.

Ingredients

• Active Ingredient: Ceftriaxone Sodium (1g)

• Inactive Ingredients: Sterile water/diluent for reconstitution

Drug Class

• Third-Generation Cephalosporin Antibiotic

Dosage Form

• Injection (Intravenous use only)

• Strength: 1g vial

Uses

• Treatment of severe bacterial infections:

  • Lower respiratory tract infections (pneumonia, bronchitis)

  • Urinary tract infections (UTIs)

  • Intra-abdominal infections (peritonitis, appendicitis)

  • Meningitis (bacterial infection of brain/spinal cord)

  • Sepsis (bloodstream infection)

  • Skin and soft tissue infections

  • Bone and joint infections

  • Gonorrhea and pelvic inflammatory disease

• Surgical prophylaxis to prevent postoperative infections

Dosage

• Adults: 1–2 g IV once daily or divided into 12-hour intervals, depending on infection type/severity

• Severe cases: Up to 4 g per day

• Children/infants: Dose adjusted according to weight and condition
  ⚠️ Must only be given under medical supervision by a healthcare professional

In Case of Overdose

• Symptoms: Seizures, irregular heartbeat, kidney/liver dysfunction

• Immediate emergency medical care required

Missed Dose

• If a scheduled dose is missed, it should be given as soon as possible by the healthcare provider

• Do not double the next dose

How To Use

• Administered by a doctor or nurse through IV infusion or slow IV injection

• Reconstituted with sterile water or compatible IV fluid before use

• Not to be self-administered without professional guidance

When Not to Use

• Allergy to ceftriaxone, other cephalosporins, or penicillin antibiotics

• Neonates (≤28 days) with hyperbilirubinemia or calcium-containing IV solutions

• Severe liver and kidney dysfunction without monitoring

• History of severe antibiotic-associated colitis

Side Effects

• Common: Injection site pain, diarrhea, nausea, rash

• Less common: Headache, dizziness, liver enzyme elevation

• Serious (rare): Severe allergic reaction, jaundice, seizures, C. difficile-associated diarrhea, kidney stones

Precautions & Warnings

• Caution in patients with:

  • Liver or kidney disease

  • Gastrointestinal disorders (especially colitis)

  • History of antibiotic allergy

• May interfere with lab tests (Coombs test, blood glucose tests)

• Use during pregnancy and breastfeeding only if prescribed by a doctor

Drug Interactions

• Calcium-containing IV solutions (risk of precipitation in lungs/kidneys in neonates)

• Aminoglycosides (e.g., gentamicin) → increased kidney toxicity risk

• Blood thinners (warfarin, heparin) → increased bleeding risk

• Probenecid → increases ceftriaxone levels

Storage/Disposal

• Store at room temperature (below 25°C) in a cool, dry place

• Keep away from direct light and moisture

• Use reconstituted solution immediately or as per hospital guidelines

• Dispose unused solution via medical waste disposal

Control Drug

• Not a controlled drug

• Prescription required

Quick Tips

• Always complete the prescribed course, even if symptoms improve early

• Do not mix with calcium-containing IV solutions

• Inform your doctor if you have diarrhea after treatment – may indicate a secondary infection

• Drink plenty of fluids unless advised otherwise by your doctor

• Do not self-inject; must only be given by a trained healthcare professional