Rocephin (1g) IV Injection | Broad-Spectrum Antibiotic for Severe Infections

Description

Rocephin (1g) IV Injection contains ceftriaxone, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, meningitis, and post-surgical infections. It works by stopping bacterial cell wall synthesis, effectively killing bacteria and preventing their growth.

Ingredients

• Active Ingredient: Ceftriaxone Sodium (1g)

• Inactive Ingredients: Sterile excipients for IV administration

Drug Class

Antibiotic – Third-Generation Cephalosporin

Dosage Form

Powder for reconstitution – IV Injection (1g Vial)

Uses

Rocephin is prescribed for:

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections (UTIs)

• Abdominal infections (peritonitis)

• Meningitis (bacterial)

• Septicemia (bloodstream infections)

• Skin, bone, and joint infections

• Surgical infection prophylaxis

Dosage

• Adults: 1–2g once daily or divided into 2 doses; in severe cases, up to 4g per day.

• Children: Dose based on weight (usually 50–75 mg/kg/day).

• Must be administered intravenously by a healthcare professional.

• Always follow your doctor’s exact prescription.

In case of Overdose

Symptoms: Seizures, severe diarrhea, nausea, confusion.
Management: Seek emergency medical care and provide supportive treatment.

Missed Dose

• In hospital settings, missed doses are uncommon.

• If missed, it should be administered as soon as possible under medical supervision.

How To Use

• Reconstitute powder with sterile diluent before injection.

• Administer slowly via IV route by a trained healthcare professional.

• Complete the full prescribed antibiotic course to prevent resistance.

When Not to Use

• Allergy to ceftriaxone, cephalosporins, or penicillin derivatives

• Neonates with hyperbilirubinemia (risk of kernicterus)

• Patients with severe allergic reactions to beta-lactam antibiotics

Side Effects

Common:

• Pain at injection site

• Diarrhea, nausea, vomiting

• Rash, headache

Serious (rare):

• Severe allergic reactions (anaphylaxis)

• Clostridium difficile-associated diarrhea

• Blood disorders (low platelets, anemia)

• Seizures (high doses or renal impairment)

Precautions & Warnings

• Use cautiously in patients with liver or kidney impairment.

• Not recommended for use with calcium-containing IV solutions in neonates.

• Inform your doctor if pregnant or breastfeeding.

• Long-term use may cause secondary infections.

Drug Interactions

May interact with:

• Calcium-containing solutions (especially in neonates)

• Aminoglycosides (increased kidney toxicity risk)

• Warfarin and other anticoagulants (increased bleeding risk)

• Probenecid (increases ceftriaxone levels in blood)

Storage/Disposal

• Store at room temperature (below 25°C).

• Protect from moisture and direct light.

• Use reconstituted solution immediately or as per manufacturer’s guidance.

• Dispose of vials and needles safely in accordance with medical waste rules.

Control Drug

Prescription-only medicine (not a controlled substance).

Quick Tips

• Complete the full course, even if you feel better.

• Inform your doctor about allergies to antibiotics before starting.

• Monitor for diarrhea or allergic reactions and seek medical help if they occur.

• Do not mix with calcium-containing IV fluids in neonates.