Ryzodeg 100IU/ml Flexpen 3ml – Insulin Injection for Diabetes Management

Description

Ryzodeg (100IU/ml) 3ml Flexpen is a combination insulin injection containing Insulin degludec (long-acting) and Insulin aspart (rapid-acting). This dual-action insulin helps manage blood sugar levels in adults, adolescents, and children with Type 1 and Type 2 Diabetes Mellitus. It provides stable, long-lasting control with immediate mealtime coverage, reducing the number of daily injections needed.

Ingredients

• Active Ingredients:

  • Insulin degludec 70% (long-acting)

  • Insulin aspart 30% (rapid-acting)

• Inactive Ingredients: Glycerol, metacresol, phenol, zinc chloride, hydrochloric acid/sodium hydroxide (pH adjustment), water for injection

Drug Class

• Antidiabetic Agent

• Long-acting and Rapid-acting Insulin Combination

Dosage Form

• Injection (Pre-filled Flexpen)

• Strength: 100 IU/ml, 3ml pen

Uses

• Management of Type 1 Diabetes Mellitus

• Management of Type 2 Diabetes Mellitus

• Provides:

  • Basal control (through insulin degludec)

  • Prandial (mealtime) control (through insulin aspart)

Dosage

• Individualized dosing based on patient’s blood glucose level, diet, and physician’s guidance

• Usually administered once or twice daily with main meals

• Dose adjustments required in case of physical activity, illness, or diet changes

⚠️ Must be prescribed and monitored by a healthcare professional.

In Case of Overdose

• May cause severe hypoglycemia (very low blood sugar)

• Symptoms: sweating, shakiness, confusion, blurred vision, seizures, loss of consciousness

• Immediate treatment: consume glucose tablets/sugar or seek emergency medical care

Missed Dose

• Take the missed dose with the next meal, if remembered soon

• If too close to the next scheduled dose, skip the missed one

• Never double the dose to make up for a missed injection

How To Use

1. Use the pre-filled Flexpen as instructed by your doctor or diabetes educator

2. Administer via subcutaneous injection in the abdomen, thigh, or upper arm

3. Rotate injection sites to avoid lipodystrophy (skin changes)

4. Do not inject directly into veins or muscles

5. Always check insulin appearance (should be clear and colorless) before use

When Not to Use

• Allergy to insulin degludec, insulin aspart, or any component of the pen

• Episodes of hypoglycemia (low blood sugar)

• Not for treatment of diabetic ketoacidosis (DKA)

• Avoid use in children under 1 year unless prescribed by a specialist

Side Effects

• Common: Hypoglycemia, injection site reactions, lipodystrophy (skin thickening or pits)

• Less common: Weight gain, headache, edema (swelling)

• Serious: Severe hypoglycemia, allergic reactions (rash, difficulty breathing, swelling of face/lips/tongue), vision problems

Precautions & Warnings

• Monitor blood glucose levels regularly

• Use with caution in kidney or liver impairment

• Adjust dose in case of stress, illness, or surgery

• Avoid alcohol as it may increase the risk of hypoglycemia

• Pregnant or breastfeeding women should use only under medical supervision

Drug Interactions

• Increased hypoglycemia risk with:

  • Sulfonylureas (e.g., glimepiride)

  • Beta-blockers (mask hypoglycemia symptoms)

  • ACE inhibitors, MAO inhibitors

• Decreased effectiveness with:

  • Corticosteroids, oral contraceptives, thyroid hormones, thiazides

Storage/Disposal

• Store unopened Flexpens in refrigerator (2–8°C)

• Do not freeze

• Once opened, can be stored at room temperature (below 30°C) for up to 28 days

• Keep away from direct heat and light

• Dispose of used pens and needles in a sharps container as per medical waste guidelines

Control Drug

• Prescription-only medicine

• Not a controlled substance

Quick Tips

• Always check your blood sugar before and after injections

• Keep a source of fast-acting sugar (glucose tablets or juice) nearby for hypoglycemia

• Do not share your Flexpen with others

• Carry medical identification (diabetic card/bracelet)

• Never skip meals after taking insulin