Velosef Injection 500mg (Cefradine) — 1 Vial

Description

Velosef (500mg) Injection contains Cefradine, a first-generation cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death. It is used for the treatment of moderate to severe bacterial infections affecting the respiratory tract, urinary tract, skin, bones, joints, and other susceptible infections.

Ingredients

• Active Ingredient: Cefradine 500mg

• Excipients: Sterile components for reconstitution

Drug Class

• First-generation Cephalosporin Antibiotic

Dosage Form

• Powder for Injection (Intravenous or Intramuscular use after reconstitution)

Uses / Indications

• Respiratory tract infections (bronchitis, pneumonia)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Bone and joint infections

• Ear, nose, and throat infections

• Septicemia (bloodstream infections)

• Post-surgical prophylaxis (prevention of infections)

Dosage

💉 Must be administered by a healthcare professional.

• Adults:

  • 500 mg to 1 g every 6–12 hours depending on severity.

  • Severe infections: up to 2 g every 8 hours.

  • Maximum: 8 g/day.

• Children:

  • 25–50 mg/kg/day divided into 2–4 doses.

  • Severe infections: up to 100 mg/kg/day.

• Renal impairment: Dose adjustment required.

In Case of Overdose

• Symptoms: Nausea, vomiting, diarrhea, seizures (rare in severe overdose).

• Management: Stop drug, provide supportive treatment, hemodialysis may help.

Missed Dose

• Administer as soon as remembered.

• Do not double the dose.

• Continue the prescribed antibiotic schedule.

How To Use

• Reconstitute vial with sterile water or compatible solution.

• Administer slowly by intramuscular (IM) injection or intravenous (IV) injection/infusion.

• Always given under medical supervision.

When Not to Use / Contraindications

• Known allergy to cephalosporins, penicillins, or beta-lactam antibiotics

• Severe kidney dysfunction (without dose adjustment)

• History of severe allergic reactions (e.g., anaphylaxis)

Side Effects

Common:

• Pain or swelling at injection site

• Nausea, vomiting, diarrhea

• Rash, itching

Serious (rare):

• Anaphylaxis (severe allergic reaction)

• Stevens–Johnson syndrome (serious skin reaction)

• Seizures (high doses in renal impairment)

• Blood disorders (low WBCs, anemia, thrombocytopenia)

Precautions & Warnings

• Use with caution in patients with kidney disease

• Cross-sensitivity with penicillin may occur

• Long-term use may lead to secondary infections (fungal/yeast overgrowth)

• Pregnancy: Use only if clearly needed

• Breastfeeding: Small amounts may pass into breast milk

Drug Interactions

• Aminoglycosides (e.g., gentamicin) → increased kidney toxicity risk

• Diuretics (e.g., furosemide) → increased nephrotoxicity

• Oral anticoagulants (e.g., warfarin) → enhanced bleeding risk

• Other antibiotics → possible altered effectiveness

Storage / Disposal

• Store at room temperature (below 25°C)

• Keep vial in a dry place, away from sunlight and moisture

• Use reconstituted solution immediately

• Discard unused solution safely

Control Drug / Prescription Status

• Prescription-only medicine

Quick Tips

• Complete the full prescribed antibiotic course, even if symptoms improve early

• Inform your doctor if you have a penicillin or cephalosporin allergy

• Report severe diarrhea — may indicate Clostridium difficile infection

• Stay hydrated during treatment