Zestoretic (20/12.5mg) Tablets
Zestoretic 20/12.5mg combines Lisinopril 20mg (an ACE inhibitor) and Hydrochlorothiazide 12.5mg (a thiazide diuretic) to provide long-lasting control of high blood pressure. This dual-action formula relaxes blood vessels and helps eliminate excess salt and water, lowering blood pressure and reducing strain on the heart. Regular use helps prevent heart attack, stroke, kidney damage, and other complications of hypertension.
Ingredients
Active Ingredients: Lisinopril 20mg, Hydrochlorothiazide 12.5mg
Inactive Ingredients: Lactose monohydrate, maize starch, magnesium stearate, calcium phosphate, film coating materials
Drug Class
Class: ACE Inhibitor (Lisinopril) + Thiazide Diuretic (Hydrochlorothiazide)
Category: Antihypertensive Combination
Dosage Form
Form: Film-coated tablet
Pack Size: 28 tablets
Uses
- Treatment of essential hypertension
- Combination therapy when single-agent treatment is insufficient
- Reducing risk of stroke, heart attack, and kidney damage
- Managing fluid retention related to blood pressure or heart disease
Dosage
- Adults: 1 tablet once daily; dosage may be adjusted by doctor
- Elderly or renal impairment: lower dose or monitoring may be required
- 💊 Take at the same time daily, preferably in the morning
- Swallow whole with water
In Case of Overdose
Symptoms: Severe dizziness, fainting, dehydration, very low blood pressure
Action: Seek emergency medical attention immediately.
Missed Dose
- Take as soon as you remember
- If close to next dose, skip the missed one
- Do not double up to make up a missed dose
How To Use
- Take once daily, ideally in the morning
- Can be taken with or without food
- Swallow whole; do not crush or chew
- Continue regularly even if feeling well
- Do not stop without consulting your doctor
When Not to Use
- Allergic to Lisinopril, Hydrochlorothiazide, or ACE inhibitors
- History of angioedema
- Severe kidney disease or dialysis
- Severe liver disease
- Pregnant or breastfeeding
- Anuria (unable to urinate)
- Taking aliskiren with diabetes or kidney problems
Side Effects
Common: Dizziness, lightheadedness, dry persistent cough, fatigue, increased urination, headache, nausea
Serious (seek immediate help): Swelling of face/lips/tongue/throat (angioedema), fainting, irregular heartbeat, dehydration/low potassium (muscle cramps, weakness), severe allergic reactions, breathing difficulty, chest tightness
Precautions & Warnings
- Avoid during pregnancy and breastfeeding
- Use cautiously in kidney impairment, diabetes, or gout
- Limit alcohol — may increase dizziness or fainting
- Monitor blood pressure, kidney function, and electrolytes
- Avoid potassium supplements or salt substitutes unless prescribed
- Inform doctor of all medications, especially diuretics or lithium
- Get up slowly from sitting or lying positions
Drug Interactions
- Potassium supplements or potassium-sparing diuretics — risk of high potassium
- NSAIDs — may reduce antihypertensive effect
- Lithium — increased toxicity risk
- Other antihypertensives — may cause excessive BP lowering
- Alcohol — may increase dizziness
- Diabetic drugs/insulin — may require monitoring
Storage/Disposal
- Store below 30°C in a cool, dry place
- Protect from sunlight and moisture
- Keep out of reach of children
- Do not use after expiry
- Dispose safely — do not flush
Control Drug
Prescription-only medicine (Not a controlled drug).
Quick Tips
- Take at the same time each morning
- Stay hydrated unless restricted
- Get up slowly to avoid dizziness
- Avoid potassium salt substitutes
- Continue even if feeling well
- Monitor blood pressure and kidney function regularly
- Report dry cough or facial swelling promptly
