Zestoretic (20/25mg) Tablets
Zestoretic 20/25mg combines Lisinopril 20mg (an ACE inhibitor) and Hydrochlorothiazide 25mg (a thiazide diuretic) to effectively manage high blood pressure. This dual-action formulation relaxes blood vessels and removes excess salt and water from the body, reducing blood pressure, fluid retention, and heart workload. Regular use helps prevent heart attack, stroke, kidney disease, and other hypertension-related complications.
Ingredients
Active Ingredients: Lisinopril 20mg, Hydrochlorothiazide 25mg
Inactive Ingredients: Lactose monohydrate, maize starch, magnesium stearate, calcium phosphate, coating materials
Drug Class
Class: ACE Inhibitor (Lisinopril) + Thiazide Diuretic (Hydrochlorothiazide)
Category: Antihypertensive Combination
Dosage Form
Form: Film-coated tablet
Pack Size: 28 tablets
Uses
- Treatment of essential hypertension
- Combination therapy when single-agent treatment is insufficient
- Reducing risk of heart attack, stroke, or kidney failure
- Management of fluid retention (edema) associated with hypertension
Dosage
- Adults: 1 tablet once daily, dose adjusted by doctor if necessary
- Elderly or kidney-impaired patients: lower starting dose may be recommended
- 💊 Take at the same time daily, preferably in the morning
- Swallow whole with a glass of water
In Case of Overdose
Symptoms: Extreme dizziness, fainting, dehydration, electrolyte imbalance, very low blood pressure
Action: Seek immediate medical attention or go to the nearest emergency facility.
Missed Dose
- Take as soon as you remember
- If close to next dose, skip the missed one
- Do not double up to make up a missed tablet
How To Use
- Take once daily, ideally in the morning to avoid nighttime urination
- Can be taken with or without food
- Continue regularly even if feeling well
- Do not stop abruptly without consulting your doctor
When Not to Use
- Allergic to Lisinopril, Hydrochlorothiazide, or other ACE inhibitors
- History of angioedema (face, lips, or throat swelling)
- Severe kidney disease or on dialysis
- Pregnancy or breastfeeding
- Severe liver disease or anuria
- Taking aliskiren with diabetes or kidney impairment
Side Effects
Common: Dizziness, lightheadedness, dry cough, headache, fatigue, increased urination, nausea, muscle cramps
Serious (seek immediate medical help): Swelling of face/lips/throat (angioedema), severe dehydration or electrolyte imbalance, fainting, irregular heartbeat, fever or sore throat, severe allergic reaction
Precautions & Warnings
- Avoid during pregnancy and breastfeeding
- Use cautiously if diabetic, gouty, or kidney/liver impaired
- Avoid alcohol — may increase dizziness or fainting
- Monitor blood pressure, kidney function, and electrolytes regularly
- Avoid potassium supplements or salt substitutes unless directed
- Rise slowly from sitting/lying to prevent dizziness
- Report persistent dry cough or facial swelling
Drug Interactions
- Potassium supplements or potassium-sparing diuretics — risk of high potassium
- NSAIDs — may reduce effectiveness
- Lithium — increases toxicity risk
- Other antihypertensives — may cause excessive blood pressure lowering
- Alcohol or sedatives — increase dizziness and fainting risk
- Diabetic drugs or insulin — may need monitoring
Storage/Disposal
- Store below 30°C in a cool, dry place
- Protect from sunlight and moisture
- Keep out of reach of children
- Do not use after expiry
- Dispose unused tablets safely — do not flush
Control Drug
Prescription-only medication (Not a controlled drug).
Quick Tips
- Take at the same time each morning
- Stay hydrated unless advised otherwise
- Avoid potassium-containing salt substitutes
- Monitor blood pressure and kidney function regularly
- Continue even if feeling better
- Do not stop suddenly; consult your doctor first
- Report swelling, dry cough, or unusual tiredness promptly
