Claforan Injection 1g (Cefotaxime) – 1 Vial (4ml)

Description

Claforan Injection contains Cefotaxime, a third-generation cephalosporin antibiotic. It is highly effective against a broad spectrum of Gram-positive and Gram-negative bacteria and is commonly used for moderate to severe bacterial infections including sepsis, pneumonia, meningitis, and urinary tract infections.

Ingredients

• Active ingredient: Cefotaxime sodium equivalent to Cefotaxime 1 g per vial

• Excipients: May include sodium carbonate or sterile diluent for reconstitution (depending on manufacturer).

Drug Class

• Antibiotic – Third-generation cephalosporin

Dosage Form

• Powder for Injection (to be reconstituted with 4 ml diluent for IV/IM use)

Uses / Indications

Claforan is indicated for treatment of infections caused by susceptible bacteria, including:

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections (complicated and uncomplicated)

• Skin and soft tissue infections

• Intra-abdominal infections (peritonitis, biliary tract infections)

• Bone and joint infections

• Bacterial meningitis

• Septicemia and endocarditis

• Gynecological infections including pelvic inflammatory disease

• Prophylaxis in surgical procedures to prevent infection

Dosage (General guidelines – individualize as per physician)

• Adults: 1 g every 8–12 hours IV/IM; may increase up to 2 g every 6–8 hours for severe infections.

• Children: 100–150 mg/kg/day in divided doses.

• Neonates: 50 mg/kg every 12 hours (first week of life), then every 8 hours.

• Maximum dose: up to 12 g/day in divided doses.

• Adjust dose in renal impairment.

In Case of Overdose

• Symptoms: Seizures, encephalopathy, neuromuscular excitability, or GI disturbances.

• Treatment: Supportive care; anticonvulsants if needed; hemodialysis may reduce drug levels.

Missed Dose

• Administer as soon as remembered.

• If near next scheduled dose, skip missed dose — do not double.

How To Use

• Reconstitute powder with sterile water or appropriate diluent.

• Administer via intramuscular injection or intravenous injection/infusion.

• Only trained healthcare professionals should prepare and administer.

When Not to Use (Contraindications)

• Known allergy to Cefotaxime or other cephalosporins.

• History of severe hypersensitivity to beta-lactam antibiotics (e.g., penicillins, carbapenems).

Side Effects

Common:

• Injection site pain or swelling

• Rash, itching

• Diarrhea, nausea, vomiting

Serious (rare):

• Severe allergic reaction (anaphylaxis)

• Pseudomembranous colitis (C. difficile diarrhea)

• Blood disorders (thrombocytopenia, leukopenia)

• Seizures (in high doses or renal impairment)

Precautions & Warnings

• Adjust dose in renal impairment to reduce risk of neurotoxicity.

• Prolonged use may cause superinfection (fungal or resistant bacteria).

• Monitor blood counts during long-term therapy.

• Use with caution in patients with GI disease, particularly colitis.

Drug Interactions

• Aminoglycosides / Loop diuretics (e.g., furosemide): Increased risk of nephrotoxicity.

• Oral anticoagulants (e.g., warfarin): May enhance anticoagulant effect.

• Chloramphenicol: May antagonize effects of cephalosporins.

Storage / Disposal

• Store below 25°C, protect from light and moisture.

• Reconstituted solution should be used immediately (or within specified time if refrigerated).

• Dispose of unused medication safely — do not reuse vials.

Control Drug / Prescription Status

• Prescription-only medicine

• Not available OTC

Quick Tips

• Claforan is a powerful hospital-grade antibiotic for serious infections.

• Always complete the prescribed course — stopping early can cause relapse or resistance.

• Inform your doctor if you are allergic to penicillins or cephalosporins.

• Report persistent diarrhea, unusual bleeding, or seizures immediately.

• Dose adjustment is essential in kidney disease.