Dormicum (5mg/5ml) Injection – Midazolam Sedative | 10 Ampoules

Description

Dormicum Injection contains Midazolam, a short-acting benzodiazepine used as a sedative, anxiolytic, and pre-anesthetic agent. It provides rapid onset of sedation and relaxation, making it suitable for use before surgery, diagnostic procedures, or in intensive care for sedation and seizure control.

Ingredients

• Active Ingredient: Midazolam Hydrochloride (5mg/5ml per ampoule)

• Excipients: Sodium chloride, hydrochloric acid/sodium hydroxide for pH adjustment, and water for injection

Drug Class

• Benzodiazepine (CNS depressant, sedative-hypnotic)

Dosage Form

• Injection (solution for IV or IM use)

• Strength: 5mg/5ml per ampoule (10 ampoules per pack)

Uses / Indications

• Sedation before surgery or medical procedures

• Anxiolysis (relief of anxiety before anesthesia)

• Induction of anesthesia

• Sedation in intensive care units (ICU)

• Control of acute seizures (status epilepticus)

• Conscious sedation during diagnostic or minor surgical procedures

Dosage

💉 Administered under strict medical supervision only

• Adults (IV):

  • Preoperative sedation: 1–2.5mg IV slowly (titrate as needed)

  • Conscious sedation: 0.5–2.5mg IV over 2 minutes, repeat if required

  • Induction of anesthesia: 0.1–0.2mg/kg IV

• Children:

  • IV: 0.05–0.1mg/kg, maximum dose depends on indication

  • IM (preoperative sedation): 0.1–0.15mg/kg

⚠️ Dose adjusted based on age, weight, and clinical condition.

In Case of Overdose

• Symptoms: Extreme drowsiness, confusion, slowed breathing, loss of consciousness, coma

• Management: Supportive care, airway management; Flumazenil (benzodiazepine antagonist) may be used as antidote under supervision

Missed Dose

• Not applicable for hospital/surgical settings

• For ICU sedation, missed doses must be adjusted by the healthcare provider

How To Use

• Administered intravenously (IV) or intramuscularly (IM) by trained healthcare professionals only

• Slow injection recommended to avoid respiratory depression

• Continuous monitoring of breathing and vital signs required

When Not to Use / Contraindications

• Hypersensitivity to Midazolam or other benzodiazepines

• Severe respiratory insufficiency or acute narrow-angle glaucoma

• Myasthenia gravis

• Shock or coma (unless under intensive monitoring)

Side Effects

Common:

• Drowsiness, dizziness

• Confusion, memory disturbance

• Pain at injection site

Serious:

• Respiratory depression or arrest

• Hypotension

• Paradoxical reactions (agitation, aggression, restlessness)

• Dependence with prolonged use

Precautions & Warnings

• Must be used in a hospital/clinical setting with airway and resuscitation equipment available

• Increased sensitivity in elderly or debilitated patients

• Use cautiously in patients with liver or kidney impairment

• May cause amnesia (loss of memory around procedure)

• Avoid alcohol and CNS depressants (increased sedation risk)

• Risk of dependence and withdrawal symptoms with prolonged use

Drug Interactions

• CNS depressants (opioids, alcohol, barbiturates): Increased sedation and respiratory depression

• Antifungal drugs (ketoconazole, itraconazole): ↑ Midazolam levels

• Macrolide antibiotics (erythromycin, clarithromycin): ↑ Midazolam effects

• HIV protease inhibitors (ritonavir): Potent increase in Midazolam concentration

Storage / Disposal

• Store at 20–25°C, protected from light

• Keep ampoules in original packaging until use

• Discard unused solution safely according to hospital guidelines

Control Drug / Prescription Status

• Controlled drug (Schedule IV benzodiazepine)

• Prescription-only

Quick Tips

• Dormicum works quickly and wears off fast, making it suitable for short procedures

• Patients should not drive or operate machinery for 24 hours after administration

• Inform doctor about liver/kidney disease, respiratory conditions, or alcohol use before administration

• Only to be used under strict medical supervision