Metomide 10 mg Injection – Box of 10 Ampoules (Metoclopramide Antiemetic / Prokinetic)

Description

Metomide injection is a parenteral form of metoclopramide, a dopamine (D₂) receptor antagonist with prokinetic and antiemetic properties. It is used to manage nausea, vomiting, and delayed gastric emptying (gastroparesis). The injectable form is typically used in hospital or clinical settings. 

Ingredients

• Active ingredient: Metoclopramide (10 mg per ampoule)

• Inactive / excipients: (formulation-specific) possibly water for injection, buffering agents, stabilizers — check manufacturer’s insert

Drug Class

Antiemetic / Prokinetic / Dopamine D₂ antagonist 

Dosage Form

Sterile injectable solution (ampoule) — 10 mg per ampoule (volume as per manufacturer)

Uses (Indications)

Metomide injection may be used in:

• Prevention or treatment of nausea and vomiting, including postoperative, chemotherapy-induced, or drug-induced vomiting 

• Management of gastroparesis or delayed gastric emptying (e.g. in diabetic patients) 

• As a prokinetic agent to stimulate GI motility in certain diagnostic procedures (e.g. to facilitate gastric emptying) 

Dosage

• The exact dose and frequency depend on patient condition, route (IV or IM), and physician’s orders. 

• In many protocols, 10 mg (one ampoule) may be given IV or IM, repeated as needed.

• For gastroparesis, such injections are often given up to 4 times daily in clinical practice. 

In Case of Overdose

• Symptoms: sedation, lethargy, extrapyramidal symptoms (dystonia, muscle spasms), hypotension, agitation, restlessness 

• Treatment: supportive care, discontinue drug, manage extrapyramidal reactions (use anticholinergics or antihistamines), monitor vital signs 

Missed Dose

• In clinical settings with injections, “missed dose” is usually handled by medical staff.

• Patients shouldn’t self-administer extra dose to compensate.

How To Use / Administration

• Administer by intravenous (IV) or intramuscular (IM) route using aseptic technique. 

• For IV use, the injection should be given slowly to reduce side effect risks. 

• Monitor patient for response and adverse effects during and after administration.

When Not to Use (Contraindications)

Metoclopramide (Metomide) should not be used in:

• Known hypersensitivity to metoclopramide or formulation ingredients

• Gastrointestinal hemorrhage, obstruction, or perforation 

• Pheochromocytoma (risk of hypertensive crisis) 

• Seizure disorder (may lower seizure threshold)

• Parkinson’s disease or other extrapyramidal disorders 

• Use beyond 12 weeks due to risk of tardive dyskinesia (movement disorder) 

Side Effects

Common / less serious:

• Drowsiness, fatigue 

• Diarrhea 

• Restlessness, agitation 

• Extrapyramidal reactions: acute dystonia, akathisia 

Serious / rare:

• Tardive dyskinesia (potentially irreversible) if used long-term

• Neuroleptic malignant syndrome (rare) 

• Galactorrhea, gynecomastia (due to hyperprolactinemia) 

• Others: movement disorders, extrapyramidal symptoms even after short term use 

Precautions & Warnings

• Limit use to short duration (≤ 12 weeks) to reduce risk of movement disorders 

• Use with caution in elderly who are more sensitive to side effects

• Monitor for extrapyramidal symptoms; discontinue if they appear

• In renal impairment, dose adjustment may be needed

• Avoid in patients with GI obstruction, bleeding, or perforation

• Avoid combining with other drugs that increase risk of movement disorders

Drug Interactions

• Additive risk of extrapyramidal effects with other dopamine antagonists or antipsychotics

• May interact with medications impacting CYP2D6 or dopamine pathways 

• Drugs with sedative properties (e.g. antihistamines, benzodiazepines) may worsen drowsiness

Storage / Disposal

• Store at controlled room temperature (per manufacturer guidelines)

• Keep away from light and moisture

• Do not freeze

• Use before expiry date

• Dispose of unused/expired ampoules safely per biomedical waste protocols

Control Drug Status

• Metoclopramide is not a narcotic or controlled drug, but it is prescription-only and must be used under physician supervision

Quick Tips

• Monitor patients closely for movement disorders, particularly in prolonged therapy

• Administer IV slowly to minimize side effects

• Use the lowest effective dose for shortest duration

• Discontinue if signs of TD (tardive dyskinesia) or extrapyramidal symptoms appear

• Caution in elderly and in patients with renal impairment