Tanzo Injection (4.5 g) – Piperacillin + Tazobactam Antibiotic

Description

Tanzo 4.5 g Injection is a broad-spectrum antibiotic containing Piperacillin (4 g) and Tazobactam (0.5 g). Piperacillin is a penicillin-type antibiotic that kills bacteria, while Tazobactam prevents bacterial resistance by inhibiting beta-lactamase enzymes. Together, they are used to treat a wide range of moderate to severe bacterial infections, especially hospital-acquired and complicated infections.

Ingredients

• Active Ingredients:

  • Piperacillin Sodium 4 g

  • Tazobactam Sodium 0.5 g

• Excipients: Buffers and stabilizers (vary by manufacturer)

Drug Class

• Beta-lactam antibiotic (Extended-spectrum Penicillin + Beta-lactamase inhibitor)

Dosage Form

• Injection (IV) – Powder for reconstitution

Uses / Indications

• Intra-abdominal infections (peritonitis, appendicitis)

• Respiratory tract infections (hospital-acquired pneumonia)

• Skin and soft tissue infections

• Urinary tract infections (complicated cases)

• Sepsis and bloodstream infections

• Gynecological infections

• Febrile neutropenia (as part of combination therapy)

Dosage (General guidance – individualized by doctor)

• Adults:

  • 4.5 g every 6–8 hours, given by IV infusion over 30 minutes.

  • Dose adjustment required in renal impairment.

• Children (>2 months): Dose based on body weight and infection type.

• Treatment duration: Depends on infection severity, usually 7–14 days.

In Case of Overdose

• Symptoms: Nausea, vomiting, diarrhea, seizures (rare), electrolyte disturbances.

• Management: Symptomatic and supportive care; hemodialysis can help remove drug.

Missed Dose

• Inform healthcare provider immediately.

• Administer missed dose as soon as possible, but do not double dose.

How To Use

• Reconstitute vial with sterile water or suitable IV fluid.

• Administer intravenously (IV) over 30 minutes.

• Given only under medical supervision in hospital/clinic settings.

When Not to Use (Contraindications)

• Allergy to penicillins, cephalosporins, or beta-lactam antibiotics

• Severe hypersensitivity reactions (e.g., anaphylaxis) in history

• Use with caution in renal impairment or seizure disorders

Side Effects

Common:

• Diarrhea, nausea, vomiting

• Headache

• Rash, itching

Serious (rare):

• Severe allergic reaction (anaphylaxis)

• Clostridium difficile-associated diarrhea

• Low platelet or white blood cell count

• Liver enzyme elevation

• Seizures (especially in high doses or renal impairment)

Precautions & Warnings

• Use with caution in patients with renal or hepatic dysfunction.

• Monitor renal function, liver enzymes, and blood counts during prolonged therapy.

• May increase risk of bleeding when used with anticoagulants.

• Prolonged use may cause superinfections (e.g., fungal).

Drug Interactions

• Anticoagulants (Warfarin, Heparin): May increase bleeding risk

• Aminoglycosides: May interact if mixed in same IV solution (separate infusions required)

• Methotrexate: Reduced clearance, risk of toxicity

• Probenecid: May increase Piperacillin levels

Storage / Disposal

• Store below 25°C, protected from light and moisture.

• After reconstitution, use immediately or within recommended stability time (as per manufacturer).

• Discard unused solution safely; do not reuse vials.

Control Drug / Prescription Status

• Prescription-only medicine

• Not an OTC product

Quick Tips

• Always complete the full prescribed course, even if symptoms improve early.

• Report any allergic reactions (rash, swelling, breathing difficulty) immediately.

• Ensure adequate hydration during treatment.

• Do not self-administer; must be given by a healthcare professional.