Cardace-H (5/12.5mg) 20 Tablets – Ramipril & Hydrochlorothiazide Combination for Hypertension & Heart Protection

Description

Cardace-H (5/12.5mg) Tablets combine Ramipril (5mg) and Hydrochlorothiazide (12.5mg) to effectively manage high blood pressure (hypertension).
This combination works by relaxing blood vessels (Ramipril) and increasing urine output (Hydrochlorothiazide), helping to lower blood pressure, reduce heart strain, and prevent complications like heart attacks, strokes, and kidney damage.

Ingredients

• Active Ingredients:

  • Ramipril 5mg

  • Hydrochlorothiazide 12.5mg

• Inactive Ingredients: Lactose monohydrate, magnesium stearate, starch, talc, and other excipients.

Drug Class

• Therapeutic Class: Antihypertensive / Cardiovascular Combination

• Pharmacological Class:

  • Ramipril – ACE Inhibitor

  • Hydrochlorothiazide – Thiazide Diuretic

Dosage Form

• Form: Tablet

• Strength: 5mg/12.5mg

• Packaging: 20 Tablets per pack

Uses

• Treatment of essential hypertension (high blood pressure)

• Management of heart failure (as part of combination therapy)

• Prevention of cardiovascular events such as heart attack and stroke

• Protection of kidney function in patients with diabetes or high blood pressure

Dosage

• Adults:

  • Usual starting dose: 1 tablet once daily.

  • May be adjusted by your physician based on blood pressure response.

• Elderly or renal-impaired patients: Lower initial dose may be recommended.

• Always take exactly as prescribed by your doctor.

In Case of Overdose

Symptoms: Severe dizziness, fainting, dehydration, or electrolyte imbalance.
Action: Seek immediate medical attention or contact a poison control center.

Missed Dose

• Take the missed dose as soon as remembered.

• Skip if it’s almost time for the next scheduled dose.

• Do not double the dose to make up for a missed one.

How To Use

• Take orally with water, preferably at the same time each day.

• Can be taken with or without food.

• Avoid excessive salt intake and stay hydrated.

• Continue taking even if you feel well — hypertension often has no symptoms.

When Not to Use

• Allergy to Ramipril, Hydrochlorothiazide, or other ACE inhibitors/thiazide diuretics

• History of angioedema (swelling of lips, face, or throat)

• Pregnancy and breastfeeding

• Severe kidney or liver disease

• Anuria (no urine output)

• Low blood pressure (hypotension)

• Electrolyte imbalance, especially low potassium or sodium

• Concurrent use with Aliskiren in diabetic patients

Side Effects

Common:

• Dry cough

• Dizziness or lightheadedness

• Fatigue

• Increased urination

• Headache

Less Common:

• Nausea or upset stomach

• Rash or itching

• Low blood pressure

Serious (seek immediate medical care):

• Swelling of the face, lips, tongue, or throat

• Severe dehydration or electrolyte imbalance

• Irregular heartbeat

• Reduced urine output

Precautions & Warnings

• Monitor blood pressure, electrolyte levels, and kidney function regularly.

• Use caution in patients with renal impairment, diabetes, or gout.

• May increase sensitivity to sunlight — use sunscreen if outdoors.

• Avoid alcohol or other blood pressure-lowering agents without consulting a doctor.

• Not recommended during pregnancy or lactation.

• Stand up slowly from sitting or lying positions to prevent dizziness.

Drug Interactions

May interact with:

• Potassium supplements or potassium-sparing diuretics – risk of hyperkalemia

• NSAIDs (e.g., ibuprofen, diclofenac) – may reduce antihypertensive effect

• Lithium – increases lithium toxicity risk

• Antidiabetic drugs or insulin – may increase risk of low blood sugar

• Other antihypertensive agents – may cause excessive blood pressure drop

• Corticosteroids or ACTH – may worsen electrolyte imbalance

Storage/Disposal

• Store below 30°C, in a cool, dry place away from light and moisture.

• Keep out of reach of children.

• Do not use after the expiry date printed on the packaging.

• Dispose of unused tablets properly; do not flush in toilets or drains.

Control Drug

• Prescription-only medicine (Rx)

• Not a controlled substance

Quick Tips

• Take Cardace-H at the same time every day for consistent results.

• Maintain a low-salt diet and drink enough fluids unless advised otherwise.

• Inform your doctor if you experience persistent cough or severe dizziness.

• Avoid alcohol and salt substitutes containing potassium.

• Regular blood tests and blood pressure checks are important during treatment.

• Do not stop taking without your doctor’s advice — sudden discontinuation may worsen blood pressure.