Zestoretic (20/12.5mg) Tablets – Lisinopril & Hydrochlorothiazide | Dual Action Blood Pressure Control (28’s)

Description

Zestoretic (20/12.5mg) Tablets combine two effective ingredients — Lisinopril, an ACE inhibitor, and Hydrochlorothiazide, a thiazide diuretic — to provide powerful and long-lasting control of high blood pressure (hypertension).
This dual-action formula works by relaxing blood vessels and helping your body eliminate excess salt and water, lowering blood pressure and reducing the strain on your heart.
Regular use of Zestoretic helps prevent heart attacks, strokes, kidney problems, and other complications related to high blood pressure.

Ingredients

• Active Ingredients:

  • Lisinopril 20mg

  • Hydrochlorothiazide 12.5mg

• Inactive Ingredients: Lactose monohydrate, maize starch, magnesium stearate, calcium phosphate, and film coating materials.

Drug Class

• Class: ACE Inhibitor (Lisinopril) + Thiazide Diuretic (Hydrochlorothiazide)

• Category: Antihypertensive Combination

Dosage Form

• Form: Film-coated tablet

• Packaging: 28 tablets per pack

Uses

Zestoretic is indicated for:

• Treatment of essential hypertension (high blood pressure)

• Combination therapy when single-agent treatment is not sufficient

• Reducing the risk of stroke, heart attack, and kidney damage

• Managing fluid retention related to blood pressure or heart disease

Dosage

• Adults:

  • Usual starting dose: 1 tablet (20/12.5mg) once daily.

  • Dosage may be adjusted by the physician depending on blood pressure response.

• Elderly or renal impairment: Lower doses or special monitoring may be needed.

• Route: Oral, swallow whole with a glass of water.

⚠️ Take at the same time every day, preferably in the morning.

In Case of Overdose

Symptoms may include severe dizziness, fainting, dehydration, or very low blood pressure.
➡️ Action: Seek emergency medical attention immediately or go to the nearest hospital.

Missed Dose

If you forget to take a dose, take it as soon as you remember.
If it’s almost time for your next dose, skip the missed one — do not double up.
⚠️ Maintain your regular dosing schedule to ensure stable blood pressure control.

How To Use

• Take once daily, ideally in the morning to avoid nighttime urination.

• Can be taken with or without food.

• Swallow with water; do not crush or chew.

• Continue taking even if you feel well — high blood pressure often has no symptoms.

• Do not stop taking Zestoretic without consulting your doctor.

When Not to Use

Do not use Zestoretic if you:

• Are allergic to Lisinopril, Hydrochlorothiazide, or other ACE inhibitors.

• Have a history of angioedema (swelling of face, lips, or throat).

• Suffer from severe kidney disease or are on dialysis.

• Have severe liver disease.

• Are pregnant or breastfeeding.

• Are unable to urinate (anuria).

• Are taking aliskiren with diabetes or kidney problems.

Side Effects

Common side effects:

• Dizziness or lightheadedness

• Dry, persistent cough (due to Lisinopril)

• Tiredness or weakness

• Increased urination

• Headache

• Nausea

Serious side effects (seek immediate help):

• Swelling of face, lips, tongue, or throat (angioedema)

• Fainting or irregular heartbeat

• Signs of dehydration or low potassium (muscle cramps, weakness)

• Severe allergic reactions or rash

• Breathing difficulty or chest tightness

Precautions & Warnings

• Avoid use during pregnancy and breastfeeding.

• Use with caution in patients with kidney impairment, diabetes, or gout.

• Limit alcohol — may increase dizziness or fainting.

• Monitor blood pressure, kidney function, and electrolytes regularly.

• Avoid potassium supplements or salt substitutes unless prescribed.

• Inform your doctor about all ongoing medications, especially diuretics or lithium.

• Get up slowly from sitting or lying positions to avoid dizziness.

Drug Interactions

Zestoretic may interact with:

• Potassium supplements or potassium-sparing diuretics (risk of high potassium).

• NSAIDs (e.g., ibuprofen, diclofenac) – may reduce blood-pressure-lowering effect.

• Lithium – increased lithium toxicity risk.

• Other antihypertensives – may cause excessive BP lowering.

• Alcohol – may enhance dizziness or lightheadedness.

• Diabetic medications or insulin – blood sugar monitoring may be needed.

Storage/Disposal

• Store below 30°C, away from direct sunlight and moisture.

• Keep out of reach of children.

• Do not use after expiry date.

• Dispose of unused or expired tablets safely; do not flush in the toilet.

Control Drug

• Not a controlled drug (Prescription-only medicine).

Quick Tips

💡 Quick Tips for Safe Use:

• Take your dose at the same time every morning.

• Avoid dehydration — drink adequate water unless restricted by your doctor.

• Get up slowly from bed to reduce dizziness risk.

• Avoid salt substitutes containing potassium.

• Continue taking even if you feel well — blood pressure control is long-term.

• Regular blood pressure and kidney function monitoring is important.

• Inform your doctor if you develop a dry cough or facial swelling.