Nezkil (600mg/300ml) IV Infusion – Linezolid Injection | 1 Vial

Description

Nezkil Infusion contains Linezolid, an oxazolidinone antibiotic. It works by inhibiting bacterial protein synthesis and is highly effective against Gram-positive infections, including drug-resistant strains like MRSA (Methicillin-Resistant Staphylococcus aureus) and VRE (Vancomycin-Resistant Enterococci). It is mainly used in serious hospital-acquired infections when other antibiotics are not effective.

Ingredients

• Active Ingredient: Linezolid 600mg

• Excipients: Water for injection, stabilizers, and isotonic solution

Drug Class

• Oxazolidinone Antibiotic

Dosage Form

• Intravenous (IV) Infusion

• Strength: 600mg/300ml

• Single-use vial

Uses / Indications

• Nosocomial pneumonia (hospital-acquired pneumonia)

• Community-acquired pneumonia caused by resistant bacteria

• Complicated and uncomplicated skin & soft tissue infections

• Bacteremia due to Gram-positive organisms

• VRE (Vancomycin-Resistant Enterococcus) infections

• Resistant MRSA infections

Dosage

💉 Adult Dose (IV Infusion):

• 600mg every 12 hours infused over 30–120 minutes

• Duration: 10–14 days (varies depending on infection type)

⚠️ No dosage adjustment required for renal or mild-to-moderate hepatic impairment.

In Case of Overdose

• Symptoms: Severe nausea, vomiting, low blood counts, lactic acidosis

• Management: Supportive care, monitoring of vital signs, hematological tests

• No specific antidote available

Missed Dose

• Administer as soon as remembered if within a reasonable timeframe

• Skip if the next scheduled dose is near

• Do not double infusions to make up for missed dose

How To Use

• For hospital or clinical administration only

• Administer by slow IV infusion over 30–120 minutes

• Do not administer as IV bolus

• Complete full course even if symptoms improve

When Not to Use / Contraindications

• Known allergy to Linezolid

• Concurrent use of MAO inhibitors (within 14 days)

• Patients with uncontrolled hypertension, pheochromocytoma, carcinoid syndrome

• Avoid in pregnancy and breastfeeding unless absolutely necessary

Side Effects

Common:

• Headache, dizziness, nausea, vomiting

• Diarrhea, abdominal discomfort

• Injection site pain

Serious:

• Bone marrow suppression → anemia, thrombocytopenia

• Peripheral and optic neuropathy (with long-term use)

• Lactic acidosis

• Serotonin syndrome (especially with SSRIs or serotonergic drugs)

• Severe allergic reactions (rash, anaphylaxis)

Precautions & Warnings

• Monitor complete blood count (CBC) if therapy exceeds 10–14 days

• Use with caution in patients with hypertension or thyroid disease

• Avoid foods high in tyramine (aged cheese, soy sauce, cured meats) → risk of hypertensive crisis

• Stop treatment if vision changes, neuropathy, or lactic acidosis symptoms develop

• Caution in prolonged use (>28 days)

Drug Interactions

• SSRIs, SNRIs, TCAs, Triptans, MAOIs: Risk of serotonin syndrome

• Adrenergic and dopaminergic agents: May cause hypertensive crisis

• Rifampicin, phenytoin: May alter effectiveness

• Tyramine-rich foods: Dangerous rise in blood pressure

Storage / Disposal

• Store at 20–25°C

• Protect from freezing and direct sunlight

• Use immediately once opened

• Discard any unused solution safely

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not a controlled substance

Quick Tips

• Avoid aged cheese, soy products, alcohol, and fermented foods while on therapy

• Report any vision problems, unusual bleeding, or numbness/tingling immediately

• Do not stop treatment early, even if symptoms improve

• Blood counts may need monitoring during prolonged therapy

• Not for self-administration – hospital use only