Novoteph (40mg) IV Injection/Infusion – Enoxaparin Sodium | Anticoagulant

Description

Novoteph (40mg) IV Injection/Infusion contains Enoxaparin Sodium, a low molecular weight heparin (LMWH). It is widely used as an anticoagulant to prevent and treat blood clots, including deep vein thrombosis (DVT), pulmonary embolism (PE), and clotting risks in hospitalized or post-surgical patients. It works by inhibiting factor Xa, reducing the body’s ability to form harmful clots while preserving normal circulation.

Ingredients

• Active Ingredient: Enoxaparin Sodium 40mg

• Excipients: Water for injection and stabilizers

Drug Class

• Anticoagulant (Low Molecular Weight Heparin – LMWH)

Dosage Form

• Injection / Infusion (IV/Subcutaneous)

• Strength: 40mg

Uses / Indications

• Prevention of deep vein thrombosis (DVT) in surgical and medical patients

• Prevention of pulmonary embolism (PE)

• Treatment of established venous thromboembolism (VTE)

• Prevention of clotting in patients on dialysis or with restricted mobility

• Part of management in acute coronary syndromes (ACS), including unstable angina and myocardial infarction

Dosage

💉 Typical Adult Dosage (for prophylaxis):

• 40mg once daily by subcutaneous injection

• For DVT/PE treatment: 1mg/kg every 12 hours or 1.5mg/kg once daily (per physician’s guidance)

⚠️ Dose must be adjusted in patients with renal impairment.

In Case of Overdose

• Symptoms: Excessive bleeding, bruising, nosebleeds, blood in urine/stool

• Management: Protamine sulfate can partially reverse anticoagulant effects

• Supportive treatment with monitoring of coagulation tests

Missed Dose

• Administer as soon as remembered if within a few hours

• Skip if near the next scheduled dose

• Do not double dose

How To Use

• Administer by deep subcutaneous injection or as prescribed infusion

• Do not inject into muscle

• Alternate injection sites to reduce irritation

• Only a healthcare professional should administer IV infusion doses

When Not to Use / Contraindications

• Allergy to enoxaparin, heparin, or pork-derived products

• Patients with active major bleeding

• History of heparin-induced thrombocytopenia (HIT)

• Severe renal impairment without dose adjustment

• Recent hemorrhagic stroke or major surgery

Side Effects

Common:

• Bruising, pain, redness at injection site

• Mild bleeding or nosebleeds

Serious (seek medical help):

• Severe bleeding (internal or external)

• Low platelet count (HIT)

• Allergic reaction: rash, itching, swelling

• Spinal/epidural hematoma → risk of paralysis (in patients receiving spinal anesthesia)

Precautions & Warnings

• Use with caution in patients with renal impairment, peptic ulcer, uncontrolled hypertension, or bleeding disorders

• Monitor platelet counts and coagulation profile during therapy

• Avoid concurrent use with NSAIDs, aspirin, or other anticoagulants unless prescribed

• Inform doctor before surgery or dental procedures

Drug Interactions

• NSAIDs (ibuprofen, diclofenac, naproxen) → Increased bleeding risk

• Aspirin, clopidogrel, warfarin → Enhanced anticoagulant effect

• Other heparins or anticoagulants → Contraindicated unless directed

Storage / Disposal

• Store at 20–25°C

• Do not freeze

• Protect from direct sunlight

• Dispose of used vials/syringes safely in sharps container

Control Drug / Prescription Status

• Prescription-only medicine (Rx)

• Not a controlled substance

Quick Tips

• Rotate injection sites to minimize bruising

• Report unusual bleeding, black stools, or severe headaches immediately

• Avoid over-the-counter painkillers unless approved by your doctor

• Patients on dialysis or with kidney issues require special monitoring

• Do not self-inject unless properly trained by a healthcare provider