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Tucana (400mg) contains Tucatinib, a targeted anticancer medication used in the treatment of advanced or metastatic HER2-positive breast cancer. It works by selectively blocking the HER2 receptor, a protein that promotes the growth of cancer cells. By inhibiting this receptor, Tucana helps slow down or stop the spread of cancer and enhances the effectiveness of other cancer treatments such as trastuzumab and capecitabine.
Ingredients
Active Ingredient: Tucatinib 400 mg
Inactive Ingredients: Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and capsule shell components.
Drug Class
Tyrosine Kinase Inhibitor (HER2 Inhibitor)
Dosage Form
Oral Capsule
Uses
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Treatment of HER2-positive metastatic or advanced breast cancer
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Used in combination with trastuzumab and capecitabine for patients who have received prior HER2-directed therapies
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May also help control cancer that has spread to other parts of the body, including the brain
Dosage
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Typical adult dose: 300 mg twice daily in combination with trastuzumab and capecitabine (actual dose may vary by brand and formulation).
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Follow your oncologist’s exact instructions.
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Swallow whole with water, do not chew or crush.
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Continue as prescribed even if you feel better.
In case of Overdose
Symptoms may include severe diarrhea, vomiting, dizziness, or liver-related side effects.
Seek immediate medical help or contact a poison control center if overdose is suspected.
Missed Dose
If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose.
Do not double up to make up for a missed dose.
How To Use
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Take by mouth with or without food at the same time each day.
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Swallow the capsule whole with a full glass of water.
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Do not open, crush, or dissolve the capsule.
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Follow the full treatment plan as directed by your oncologist.
When Not to Use
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If allergic to Tucatinib or any of its components
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In patients with severe liver impairment unless under close medical supervision
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During pregnancy or breastfeeding unless the potential benefit outweighs the risk
Side Effects
Common: Diarrhea, nausea, fatigue, abdominal pain, vomiting, rash
Less common: Loss of appetite, mouth sores, headache
Serious (seek medical help immediately): Liver problems (yellowing of skin/eyes, dark urine), severe diarrhea, chest pain, or breathing difficulties
Precautions & Warnings
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Regular monitoring of liver function is required during treatment.
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Use effective contraception during and for at least 1 week after treatment.
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Avoid alcohol and other medications that may affect the liver.
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Inform your doctor about all ongoing medications and any history of heart or liver disease.
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Not recommended for use during pregnancy or breastfeeding.
Drug Interactions
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May interact with strong CYP3A inducers or inhibitors (e.g., rifampicin, ketoconazole, clarithromycin).
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Avoid coadministration with drugs that affect liver enzymes or transporters.
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Inform your doctor if taking hormonal contraceptives, as their effectiveness may be reduced.
Storage/Disposal
Store at room temperature (below 30°C), protected from moisture and light.
Keep out of reach of children.
Do not use after the expiry date.
Dispose of unused or expired capsules as per medical waste guidelines.
Control Drug
Prescription-only anticancer medication. Not a controlled substance.
Quick Tips
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Always take under the supervision of a qualified oncologist.
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Take exactly as prescribed, even if symptoms improve.
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Report any unusual fatigue, yellowing of the skin, or persistent diarrhea immediately.
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Do not stop the medicine suddenly without consulting your doctor.
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Maintain hydration and a healthy diet to manage side effects.