Bosmon 62.5mg Tablets (14’s) – Treatment for Pulmonary Arterial Hypertension (Bosentan)

Description

Bosmon 62.5mg Tablets contain Bosentan, an endothelin receptor antagonist (ERA) used to treat pulmonary arterial hypertension (PAH) — a condition where the blood pressure in the lungs’ arteries is abnormally high. Bosmon works by blocking the action of endothelin, a natural substance that causes blood vessels to narrow. By relaxing and widening these vessels, Bosmon reduces the workload on the heart and improves exercise capacity and quality of life in patients with PAH.

Ingredients

• Active Ingredient: Bosentan 62.5mg

• Inactive Ingredients: Maize starch, pregelatinized starch, magnesium stearate, povidone, talc, and other standard excipients

Drug Class

• Therapeutic Class: Pulmonary Hypertension Treatment

• Pharmacological Class: Endothelin Receptor Antagonist (ERA)

Dosage Form

• Form: Tablet

• Strength: 62.5mg

• Packaging: 14 Tablets per pack

Uses

• Treatment of Pulmonary Arterial Hypertension (PAH) to improve exercise capacity and slow disease progression

• May also be used for digital ulcers in systemic sclerosis (as prescribed by your doctor)

Dosage

• Adults (PAH):

  • Starting dose: 62.5mg twice daily for the first 4 weeks

  • Maintenance dose: 125mg twice daily after the initial 4 weeks, as advised by your doctor

• Children (under 12 years): Dose to be determined by the physician based on weight

• Always follow your doctor’s dosing instructions.

In Case of Overdose

Symptoms: Severe drop in blood pressure, dizziness, nausea, vomiting, or fainting.
Action: Seek emergency medical attention immediately. Supportive treatment may be required to stabilize blood pressure and heart rate.

Missed Dose

• Take the missed dose as soon as you remember.

• If it’s almost time for your next dose, skip the missed one.

• Do not double the next dose to compensate.

How To Use

• Take orally, with or without food.

• Swallow the tablet whole with a glass of water.

• Take at the same time each day to maintain consistent levels in your body.

• Continue treatment regularly, as prescribed. Do not stop without consulting your doctor.

When Not to Use

• Allergy to Bosentan or any component of the tablet

• Pregnancy or planning to conceive (Bosentan can cause severe birth defects)

• Severe liver impairment

• Concomitant use with cyclosporine A

• Breastfeeding

• Children under 12 years unless prescribed by a specialist

Side Effects

Common:

• Headache

• Flushing

• Leg swelling (edema)

• Nasal congestion

• Low blood pressure

Less Common:

• Fatigue or dizziness

• Nausea or vomiting

• Stomach pain

• Abnormal liver function test results

Serious (seek medical attention):

• Yellowing of skin or eyes (jaundice)

• Unusual tiredness or weakness

• Shortness of breath worsening

• Signs of allergic reaction (swelling of face, lips, or throat)

• Decrease in red blood cells (anemia)

Precautions & Warnings

• Regularly monitor liver function and hemoglobin levels during therapy.

• Women of childbearing age must use reliable contraception during and one month after treatment.

• Do not use during pregnancy or breastfeeding.

• May cause dizziness — avoid driving or operating machinery until you know how it affects you.

• Inform your doctor if you have heart failure, low blood pressure, or liver/kidney disease.

• Avoid alcohol — it may increase the risk of liver side effects.

• Do not stop the medicine suddenly; your doctor will gradually reduce the dose.

Drug Interactions

May interact with:

• Cyclosporine A (contraindicated – increases Bosentan levels dangerously)

• Warfarin or other blood thinners (may alter their effects)

• Rifampicin, ketoconazole, fluconazole (can affect drug metabolism)

• Hormonal contraceptives (Bosentan reduces their effectiveness – use additional non-hormonal methods)

• Sildenafil or tadalafil (may increase blood pressure-lowering effect)

• Other PAH medications – only under medical supervision

Always inform your doctor about all prescription, non-prescription, and herbal medicines you use.

Storage/Disposal

• Store below 30°C in a cool, dry place.

• Protect from light and moisture.

• Keep out of reach of children.

• Do not use after the expiry date.

• Dispose of unused or expired tablets properly — do not flush down the toilet.

Control Drug

• Prescription-only medicine (Rx)

• Not a controlled substance, but regulated for hospital and specialist use

Quick Tips

• Take Bosmon exactly as prescribed — do not skip doses.

• Monthly liver function tests are essential during treatment.

• Avoid pregnancy — use effective contraception (non-hormonal).

• Report symptoms like fatigue, yellowing of eyes, or dark urine immediately.

• Limit alcohol intake to reduce strain on the liver.

• Continue treatment even if you feel better — PAH requires long-term management.

• Do not stop medicine suddenly — consult your doctor for tapering instructions.