Oxidil Injection (500mg) – Cefuroxime IM Antibiotic for Bacterial Infections

Description

Oxidil (500mg) IM Injection contains Cefuroxime Sodium, a second-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections by inhibiting bacterial cell wall synthesis, leading to the destruction of bacteria. Oxidil is effective against both gram-positive and gram-negative bacteria, making it a versatile option for moderate to severe infections.

Ingredients

• Active Ingredient: Cefuroxime Sodium (500mg)

• Excipients: Sodium carbonate, sterile water for injection

Drug Class

• Cephalosporin Antibiotic (Second Generation)

Dosage Form

• Injection – 500mg vial for intramuscular (IM) use

Uses / Indications

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Bone and joint infections

• Septicemia (bloodstream infections)

• Intra-abdominal infections

• Meningitis (caused by susceptible organisms)

• Prophylaxis in surgical infections

Dosage (general guidance, individualized by physician)

• Adults: 750 mg to 1.5 g every 8 hours, depending on severity (500mg dose used for mild/moderate cases).

• Children: 30–100 mg/kg/day in 3–4 divided doses.

• Adjust dose in renal impairment.

• Duration: usually 7–10 days, or as prescribed by physician.

In Case of Overdose

• May cause neurological symptoms (e.g., seizures, confusion, encephalopathy).

• Management: supportive care, control of seizures, and hemodialysis in severe renal impairment.

Missed Dose

• If a dose is missed, it should be administered as soon as possible.

• If it is close to the next scheduled dose, skip the missed dose.

• Do not double inject to compensate.

How To Use

• Administered via intramuscular injection by a healthcare professional.

• Reconstitute vial with sterile water for injection before use.

• Inject deeply into a large muscle mass to minimize local irritation.

When Not to Use (Contraindications)

• Known hypersensitivity to cefuroxime, cephalosporins, or severe allergy to penicillins.

• Previous severe allergic reaction (anaphylaxis) to beta-lactam antibiotics.

Side Effects

Common:

• Pain or redness at injection site

• Diarrhea, nausea, vomiting

• Skin rash

Serious:

• Severe allergic reactions (swelling, difficulty breathing, anaphylaxis)

• Clostridium difficile-associated diarrhea

• Seizures (rare, high doses)

• Kidney or liver function changes

Precautions & Warnings

• Use with caution in patients with history of penicillin allergy.

• Monitor kidney function in long-term use or elderly patients.

• Prolonged use may lead to superinfection with resistant organisms.

• Safe in pregnancy and breastfeeding under medical supervision.

Drug Interactions

• Probenecid increases cefuroxime levels by reducing renal excretion.

• Concomitant use with loop diuretics or aminoglycosides may increase risk of nephrotoxicity.

• May interfere with some urine glucose tests (false positives).

Storage / Disposal

• Store vials at below 25°C, protected from light and moisture.

• Reconstituted solution should be used immediately.

• Dispose of needles and vials in sharps containers.

Control Drug / Prescription Status

• Prescription-only medicine

• To be used under medical supervision only

Quick Tips

• Complete the full course even if symptoms improve early.

• Report any allergic reactions or severe diarrhea immediately.

• Avoid alcohol during treatment for best recovery.

• Stay hydrated and rest to support infection recovery.