Avil 25 mg / 2 ml Injection – Box of 50 Ampoules

Description

Avil injection (pheniramine maleate) is an antihistamine preparation used to manage allergic reactions. It works by blocking histamine effects in the body, helping reduce itching, swelling, rash, hives, and other allergic symptoms. The 2 ml ampoule delivers 25 mg dosage. It is used in hospital or clinical settings under physician supervision.

Ingredients

• Active ingredient: Pheniramine maleate (25 mg per 2 ml)

• Excipients / Inactive ingredients: (as per manufacturer — e.g., water for injection, stabilizers)

Drug Class

Antihistamine (first-generation) / H1 receptor antagonist

Dosage Form

Sterile injection solution (ampoule) — 2 ml per ampoule, each containing 25 mg pheniramine maleate.

Uses (Indications)

Avil injection may be used in the following situations:

• Treatment of moderate to severe allergic reactions (urticaria, angioedema)

• Drug-induced hypersensitivity reactions

• Allergic conjunctivitis, allergic rhinitis

• Insect bite / sting reactions

• To manage pruritus (severe itching) in certain dermatological conditions

• As adjunct therapy in anaphylactic reactions (under supervision)

Dosage

• Adults / Adolescents (≥ 12 years): Typically 1–2 ml (i.e. 12.5–25 mg) intramuscularly (IM) or slowly intravenous (IV) (not faster than ~1 ml per minute) depending on severity. 

• Children: Dose must be adjusted based on age / weight; use under medical supervision. Some sources mention e.g. 0.5–0.7 ml for children 2 years old, etc. 

• The dose may be repeated every 12 hours or as directed by a physician if needed. 

⚠️ Always follow physician’s orders and refer to the specific product insert for dosing.

In Case of Overdose

• Symptoms: excessive sedation, respiratory depression, convulsions, hypotension, tachycardia, anticholinergic effects (dry mouth, urinary retention)

• If overdose is suspected: seek medical attention immediately

• Provide supportive measures, gastric lavage if recent ingestion, activated charcoal, monitoring of vital signs

Missed Dose

• Typically, for injections given in clinical settings, missed doses are handled by the treating medical professional.

• Do not self-administer extra dose to compensate.

How to Use / Administration

• Use intramuscular (IM) or slow intravenous (IV) route.

• IV should be slow (approximately 1 ml per minute) to reduce risk of adverse effects. 

• Ensure aseptic technique and correct dilution (if required by manufacturer).

• Monitor patient during and after administration.

When Not to Use (Contraindications)

• Known hypersensitivity / allergy to pheniramine or similar antihistamines

• Acute asthma (unless under strict supervision)

• Narrow-angle glaucoma

• Prostatic hypertrophy with urinary retention

• Severe cardiovascular disease

• During pregnancy or lactation, only if benefit justifies risk (use caution)

• In children under certain ages unless prescribed

Side Effects

Common:

• Drowsiness, sedation

• Dizziness

• Dry mouth

• Blurred vision

• Nausea

• Urinary retention

Less common / Serious:

• Confusion, hallucinations

• Tachycardia or palpitations

• Hypotension

• Allergic reactions (rash, swelling)

• CNS depression, respiratory depression

Precautions & Warnings

• Use with caution in patients with cardiovascular disease, hypertension, liver or kidney impairment

• Avoid use with other CNS depressants, alcohol

• May impair ability to drive or operate machinery

• In elderly patients, increased sensitivity to sedative effects

• Monitor for anticholinergic effects (dryness, urinary retention)

• If asthma or respiratory issues, use carefully

Drug Interactions

• Sedatives, hypnotics, alcohol — additive CNS depression

• Tricyclic antidepressants, MAO inhibitors — potential for additive anticholinergic effects

• Other antihistamines or anticholinergic drugs — increased side effects

• Drugs that prolong QT interval — caution

Storage / Disposal

• Store at room temperature, protected from light

• Do not freeze

• Use before expiry date

• Dispose of unused or expired ampoules safely (follow biomedical waste rules)

Control Drug Status

• Not typically a narcotic or controlled substance, but prescription and medical oversight required

Quick Tips

• Always confirm the correct dose and dilution before administration

• Administer IV injections slowly to avoid adverse reactions

• Monitor patients after injection for sedation or respiratory depression

• Avoid combining with alcohol or other sedatives

• Keep ready emergency support if allergic reaction worsens