Hyzonate 250mg Injection (Hydrocortisone Sodium Succinate) – Corticosteroid for Severe Inflammation, Allergy & Adrenal Crisis

Description

Hyzonate 250mg Injection contains Hydrocortisone Sodium Succinate, a powerful corticosteroid medicine used to treat severe inflammation, adrenal insufficiency, allergic reactions, asthma, arthritis, and life-threatening emergencies such as anaphylaxis, septic shock, and adrenal crisis.

It provides rapid relief by suppressing inflammation and replacing cortisol in patients with adrenal gland problems. This injection is usually given by a doctor or healthcare professional through intravenous (IV) or intramuscular (IM) routes.

Ingredients

• Active Ingredient: Hydrocortisone Sodium Succinate (250mg)

• Inactive Ingredients: Stabilizers and sterile water for injection

Drug Class

• Corticosteroid / Glucocorticoid

Dosage Form

• Injection (1 Vial, 250mg)

Uses

Hyzonate 250mg Injection is prescribed for:

• Adrenal insufficiency & adrenal crisis (Addison’s disease)

• Severe allergic reactions (anaphylaxis, angioedema)

• Asthma attacks & COPD exacerbations

• Rheumatic disorders (arthritis, lupus, joint inflammation)

• Endocrine disorders needing cortisol replacement

• Shock & critical illness (septic shock, trauma, post-surgery)

• Skin & autoimmune conditions (psoriasis, lupus)

• Inflammatory bowel disease (ulcerative colitis, Crohn’s disease)

Dosage

• Adults:

  • Initial: 100–250mg IV or IM, depending on severity.

  • Maintenance: May repeat every 6–8 hours, or as prescribed.

• Children:

  • Dose is weight-based (0.56–8mg/kg/day).

• Always follow doctor’s prescription.

In Case of Overdose

• Symptoms: Mood swings, confusion, high blood pressure, electrolyte imbalance, high blood sugar.

• Seek emergency medical help immediately.

Missed Dose

• As this injection is usually given in hospitals, missed doses are rare.

• If using at home, take as soon as remembered unless close to the next dose. Do not double dose.

How To Use

• Administered IV (intravenous) or IM (intramuscular) under medical supervision.

• Not for self-use unless prescribed and trained.

• Dose and duration depend on patient’s condition.

When Not to Use

Do not use Hyzonate 250mg if:

• You are allergic to Hydrocortisone or other corticosteroids

• You have untreated fungal infections

• You are receiving live vaccines (risk of severe infection)

• You have severe uncontrolled infections without antibiotics

Side Effects

Common:

• Pain, redness, or swelling at injection site

• Nausea, upset stomach

• Headache, dizziness

• Mood changes (anxiety, irritability)

Serious (long-term/high doses):

• High blood sugar (diabetes worsening)

• Increased blood pressure

• Vision changes (cataracts, glaucoma)

• Weak bones (osteoporosis)

• Swelling of face/feet (fluid retention)

• Higher risk of infections

Precautions & Warnings

• Use cautiously in diabetes, hypertension, heart disease, osteoporosis, and liver/kidney disease.

• Do not stop suddenly; taper dose gradually under medical advice.

• Avoid contact with people having chickenpox or measles.

• Pregnant & breastfeeding women should consult doctor before use.

Drug Interactions

• NSAIDs (aspirin, ibuprofen – ↑ ulcer risk)

• Antidiabetic drugs (may reduce effect, ↑ sugar levels)

• Antifungals (ketoconazole ↑ steroid levels)

• Anticonvulsants (phenytoin, carbamazepine ↓ steroid effect)

• Diuretics (low potassium risk)

• Live vaccines (dangerous infections possible)

Storage/Disposal

• Store below 25°C, away from light and heat.

• Do not freeze.

• Keep out of reach of children.

• Dispose of unused vials safely as per pharmacist’s instructions.

Control Drug

• Not a controlled substance.

• Prescription-only medicine (Rx).

Quick Tips

• Do not stop suddenly if on long-term therapy – taper slowly.

• Carry a steroid card/medical ID if on prolonged corticosteroid treatment.

• Take calcium + vitamin D to protect bone health.

• Regularly check blood pressure, blood sugar, and weight.

• Always inform doctor before vaccination or surgery.