Kanacyn Injection (1g/4ml Vial) – Kanamycin Aminoglycoside Antibiotic

Description

Kanacyn (1g/4ml) Injection contains Kanamycin Sulfate, an aminoglycoside antibiotic used to treat severe bacterial infections, particularly when other antibiotics are ineffective. It works by inhibiting bacterial protein synthesis, leading to bacterial cell death. Due to its strong potency, Kanacyn is usually reserved for resistant infections under hospital supervision.

Ingredients

• Active Ingredient: Kanamycin Sulfate (1g/4ml)

• Excipients: Water for injection and stabilizers

Drug Class

• Aminoglycoside Antibiotic

Dosage Form

• Injection – Vial containing 1g in 4ml solution (for IM or IV use)

Uses / Indications

• Treatment of serious bacterial infections, including:

  • Respiratory tract infections (pneumonia, bronchitis)

  • Urinary tract infections (complicated/severe)

  • Intra-abdominal infections

  • Septicemia (blood infections)

  • Bone and joint infections

  • Tuberculosis (as part of combination therapy)

• Used in cases where other antibiotics (penicillins, cephalosporins) are ineffective

Dosage (general guidance, individualized by physician)

• Adults: 15 mg/kg/day divided into 2–3 doses IM or IV (maximum 1.5g/day).

• Children: 15–30 mg/kg/day divided into 2–3 doses.

• Tuberculosis: 1g daily (in combination with other anti-TB drugs).

• Duration of therapy: usually 7–10 days (longer for TB, under strict monitoring).

• Dose adjustment required in renal impairment.

In Case of Overdose

• May cause ototoxicity (hearing loss, dizziness), nephrotoxicity (kidney damage), neuromuscular blockade (breathing difficulty).

• Management: discontinue drug, provide supportive treatment, and perform hemodialysis if required.

Missed Dose

• Administer as soon as remembered if not close to the next dose.

• Do not double inject to make up for missed doses.

• For best results, maintain consistent dosing schedule.

How To Use

• Administered by intramuscular (IM) injection or intravenous (IV) infusion.

• Should only be given by a healthcare professional.

• Adequate hydration must be maintained during therapy.

When Not to Use (Contraindications)

• Hypersensitivity to Kanamycin or other aminoglycosides

• Pre-existing hearing loss or vestibular dysfunction

• Severe kidney impairment (unless dose is adjusted)

• Myasthenia gravis (risk of worsened muscle weakness)

Side Effects

Common:

• Pain, redness, or swelling at injection site

• Nausea, vomiting

• Mild rash, fever

Serious:

• Ototoxicity: hearing loss, tinnitus, balance issues

• Nephrotoxicity: reduced urine output, kidney dysfunction

• Neuromuscular blockade: muscle weakness, respiratory depression

• Allergic reactions (rare but serious)

Precautions & Warnings

• Requires close monitoring of renal function, auditory function, and serum drug levels.

• Use with caution in elderly patients and those with pre-existing kidney or ear problems.

• Avoid prolonged use to reduce risk of toxicity.

• Not recommended during pregnancy unless absolutely necessary (may cause fetal harm).

• Minimal excretion into breast milk – use with caution in nursing mothers.

Drug Interactions

• Increased toxicity risk with:

  • Other nephrotoxic drugs (vancomycin, amphotericin B, cisplatin)

  • Other ototoxic drugs (loop diuretics like furosemide, ethacrynic acid)

• May enhance neuromuscular blockade when used with muscle relaxants.

Storage / Disposal

• Store at 20–25°C, away from heat, moisture, and direct sunlight.

• Do not freeze.

• Use reconstituted solution immediately.

• Dispose of vials and needles safely in sharps containers.

Control Drug / Prescription Status

• Prescription-only medicine

• Hospital/clinic use recommended under specialist supervision

Quick Tips

• Reserved for serious infections resistant to other antibiotics.

• Regular monitoring of kidney and hearing function is essential.

• Stay hydrated to protect kidney function.

• Report symptoms such as hearing problems, dizziness, or reduced urine output immediately.

• Do not self-administer without medical guidance.