Nalbin 10 mg Injection (Nalbuphine Hydrochloride) – 1 mL, Pack of 10 Ampoules

Description

Nalbin Injection contains Nalbuphine Hydrochloride, an opioid analgesic used for the relief of moderate to severe pain. It is structurally related to morphine but has both agonist and antagonist activity, providing pain relief with a potentially lower risk of respiratory depression compared to pure opioid agonists. It is commonly administered in hospitals for postoperative pain, labor pain, and pain due to serious conditions such as myocardial infarction or trauma.

Ingredients

• Active Ingredient: Nalbuphine Hydrochloride 10 mg per 1 mL ampoule

• Excipients: Sterile water for injection and stabilizers (as per manufacturer’s formulation)

Drug Class

• Opioid analgesic (agonist–antagonist opioid)

Dosage Form

• Injection

• Strength: 10 mg / 1 mL

• Pack: 10 Ampoules

Uses / Indications

• Relief of moderate to severe pain, including postoperative pain

• Pain during labor and delivery

• As a supplement to anesthesia (preoperative or operative)

• Short-term management of pain in myocardial infarction or trauma

Dosage

• Adults:

  • 10 mg every 3–6 hours as needed (usual range 10–20 mg per dose)

  • Maximum daily dose: 160 mg/day

• Children (>18 months): 0.2–0.3 mg/kg every 3–4 hours (maximum 2.5 mg/kg/day)

• Route: Intravenous (IV), Intramuscular (IM), or Subcutaneous (SC) injection

• Dosage must always be individualized based on severity of pain and patient’s response

In Case of Overdose

• Symptoms: Severe respiratory depression, extreme drowsiness, hypotension, bradycardia, coma

• Management:

  • Airway support and assisted ventilation

  • Administration of naloxone (opioid antagonist)

  • Supportive cardiovascular care

Missed Dose

• Nalbin is usually administered in hospital under supervision, so missed doses are unlikely

• If used at home, take only as prescribed and never double dose to make up for a missed one

How To Use / Administration Instructions

1. Administer via IM, IV, or SC injection under medical supervision.

2. Inspect ampoule before use; solution should be clear and particle-free.

3. Do not self-administer; only trained healthcare professionals should inject.

4. Injection should be slow (especially IV) to reduce side effects like dizziness or nausea.

When Not to Use / Contraindications

• Hypersensitivity to nalbuphine or other opioids

• Patients with respiratory depression not under monitoring

• Acute or severe bronchial asthma without resuscitation equipment available

• Patients receiving opioid agonists (e.g., morphine, fentanyl, methadone) for chronic pain — may precipitate withdrawal

• Use with caution in patients with head injury, increased intracranial pressure, or impaired consciousness

Side Effects / Adverse Reactions

Common:

• Drowsiness, dizziness, headache

• Nausea, vomiting, dry mouth

• Sweating, flushing

• Injection site reactions

Serious (less common):

• Respiratory depression

• Bradycardia, hypotension

• Allergic reactions (rash, itching, swelling)

• Dependence with prolonged use (lower risk than morphine but still possible)

Precautions & Warnings

• Use with caution in patients with renal or hepatic impairment

• Avoid alcohol and other CNS depressants (enhances sedative effect)

• May impair ability to drive or operate machinery

• Use in pregnancy: crosses placenta — may cause neonatal respiratory depression; only use if clearly needed

• Lactation: may pass into breast milk, use cautiously

• Monitor closely in elderly patients

Drug Interactions

• CNS depressants (alcohol, benzodiazepines, sedatives): ↑ risk of respiratory depression and sedation

• Other opioids (morphine, methadone, fentanyl): may precipitate withdrawal symptoms

• MAO inhibitors, antidepressants, antipsychotics: risk of enhanced CNS depression

• Anesthetics or muscle relaxants: additive CNS and respiratory effects

Storage / Disposal

• Store below 25°C; protect from light and freezing

• Keep in original packaging until use

• Discard unused solution safely in accordance with medical waste disposal guidelines

• Keep out of reach of children

Control Drug / Prescription Status

• Prescription-only controlled medicine

• Use restricted to healthcare facilities or under physician supervision

Quick Tips

• Nalbin may cause drowsiness — avoid driving or operating heavy machinery

• Do not use alcohol while on this medicine

• Inform your doctor if you are taking other painkillers or sedatives

• Always take the lowest effective dose for the shortest possible duration

• Report immediately if experiencing difficulty breathing or severe dizziness