Nalbin 20 mg/mL Injection (Nalbuphine Hydrochloride) – Pack of 10 Ampoules

Description

Nalbin Injection contains Nalbuphine Hydrochloride, a synthetic opioid analgesic with agonist–antagonist activity. It provides effective relief for moderate to severe pain and is often used in postoperative pain management, labor pain, and trauma-related pain. Compared to pure opioids, Nalbin has a lower risk of respiratory depression, though caution is still required.

Ingredients

• Active Ingredient: Nalbuphine Hydrochloride 20 mg per mL

• Excipients: Sterile water for injection and stabilizers (per manufacturer’s formula)

Drug Class

• Opioid Analgesic (Agonist–Antagonist)

Dosage Form

• Injection

• Strength: 20 mg/mL

• Pack: 10 Ampoules

Uses / Indications

• Moderate to severe acute pain

• Postoperative pain relief

• Pain during labor and delivery

• Supplement to anesthesia (pre-, intra-, or postoperative)

• Pain management in myocardial infarction and trauma cases

Dosage

• Adults:

  • 10–20 mg every 3–6 hours as needed

  • Maximum daily dose: 160 mg

• Children (>18 months): 0.2–0.3 mg/kg every 3–4 hours (not to exceed 2.5 mg/kg/day)

• Routes: IV (intravenous), IM (intramuscular), or SC (subcutaneous)

• Dosage must be individualized according to pain severity and patient’s response

In Case of Overdose

• Symptoms: Respiratory depression, sedation, hypotension, coma

• Treatment:

  • Ensure airway patency, provide ventilatory support

  • Administer naloxone (opioid antagonist)

  • Symptomatic and supportive care

Missed Dose

• Nalbin is usually hospital-administered; missed doses are rare

• If self-administered, never double dose — resume as per schedule with doctor’s advice

How To Use / Administration Instructions

1. Administer by IV, IM, or SC injection under medical supervision.

2. Inspect ampoule before use; solution should be clear.

3. Inject IV doses slowly to reduce risk of side effects.

4. Only healthcare professionals should prepare and administer.

When Not to Use / Contraindications

• Allergy to nalbuphine or other opioids

• Patients with respiratory depression not under monitoring

• Acute/severe asthma without access to resuscitation

• Concomitant use with opioid agonists (e.g., morphine, methadone) in dependent patients – may cause withdrawal

• Use cautiously in head injury, raised intracranial pressure, or reduced consciousness

Side Effects / Adverse Reactions

Common:

• Drowsiness, dizziness, headache

• Nausea, vomiting, dry mouth

• Sweating, flushing, injection site pain

Serious (rare):

• Respiratory depression

• Bradycardia, hypotension

• Allergic reactions (rash, itching, swelling, anaphylaxis)

• Dependence with prolonged use

Precautions & Warnings

• Use cautiously in renal or hepatic impairment

• Avoid alcohol and sedative drugs during therapy

• May impair alertness — avoid driving or operating heavy machinery

• Pregnancy: crosses placenta — may cause newborn respiratory depression

• Breastfeeding: passes into breast milk; use cautiously

• Monitor elderly patients closely

Drug Interactions

• CNS depressants (alcohol, benzodiazepines, sedatives): ↑ risk of sedation/respiratory depression

• Other opioids (morphine, fentanyl, methadone): withdrawal risk in dependent patients

• MAO inhibitors, antidepressants, antipsychotics: additive CNS effects

• Anesthetics and muscle relaxants: enhanced respiratory depression

Storage / Disposal

• Store below 25°C

• Protect from light and freezing

• Keep in original ampoule packaging until use

• Discard unused contents safely via medical waste protocols

• Keep out of children’s reach

Control Drug / Prescription Status

• Prescription-only controlled medicine

• Restricted to use under physician supervision in healthcare settings

Quick Tips

• Nalbin may cause drowsiness — avoid driving or handling machinery

• Do not consume alcohol while using this injection

• Always use the lowest effective dose for the shortest duration

• Inform your doctor about any other medications you are taking

• Report breathing problems or severe dizziness immediately