NovoMix 50 FlexPen (100IU/ml) – 3ml × 5 Prefilled Pens

Description

NovoMix 50 is a biphasic insulin analogue containing 50% soluble insulin aspart and 50% insulin aspart protamine crystals. It is used to control high blood sugar levels in patients with type 1 and type 2 diabetes mellitus. The insulin provides both rapid-acting and intermediate-acting effects, helping to manage blood glucose after meals and throughout the day.

Each FlexPen contains 3ml (100IU/ml) of prefilled insulin, making administration more convenient and accurate for diabetic patients.

Ingredients

• Active Ingredient: Insulin Aspart (100 IU/ml, biphasic formulation – 50% soluble, 50% protamine-crystallized)

• Inactive Ingredients: Glycerol, phenol, metacresol, zinc chloride, hydrochloric acid/sodium hydroxide (pH adjustment), water for injection

Drug Class

Antidiabetic (Insulin analogue, biphasic formulation)

Dosage Form

Prefilled FlexPen injection – 3ml each (Pack of 5 pens)

Uses

• Treatment of Type 1 diabetes mellitus

• Treatment of Type 2 diabetes mellitus when oral medications are not enough

• Helps control post-meal blood sugar spikes

• Maintains stable glucose control throughout the day

Dosage

• Individualized dose as prescribed by doctor

• Typically injected immediately before meals

• Dose depends on blood glucose levels, diet, physical activity, and overall health

• Must not be used without medical supervision

In Case of Overdose

• Symptoms: Sweating, shakiness, dizziness, headache, confusion, rapid heartbeat, fainting, seizures

• Management: Immediate intake of fast-acting sugar (glucose tablets, juice, or candy). Severe cases may require glucagon injection or hospitalization.

Missed Dose

• Take the missed dose as soon as remembered, but do not double dose

• Monitor blood glucose closely if a dose is missed

How to Use

• Inject subcutaneously (under the skin), usually in the thigh, upper arm, or abdomen

• Rotate injection sites to prevent lipodystrophy (fat tissue changes)

• Do not inject into a vein or muscle unless instructed

• Use FlexPen as instructed by healthcare provider

• Never share your insulin pen with others

When Not to Use

• Allergy to insulin aspart or any ingredients in the formulation

• During hypoglycemia (low blood sugar attack)

• Without doctor’s prescription and supervision

Side Effects

• Common: Hypoglycemia (low blood sugar), redness, swelling, or itching at injection site

• Moderate: Weight gain, mild swelling, headache, dizziness

• Serious: Severe hypoglycemia, blurred vision, difficulty breathing, severe allergic reaction (anaphylaxis), lipodystrophy at injection site

Precautions & Warnings

• Monitor blood glucose regularly

• Use with caution in patients with liver or kidney disease

• Inform doctor if pregnant or breastfeeding – dosage adjustments may be required

• Avoid alcohol (increases risk of hypoglycemia)

• Do not stop insulin suddenly without medical advice

Drug Interactions

• Oral antidiabetic drugs (e.g., metformin, sulfonylureas)

• Beta-blockers (mask symptoms of hypoglycemia)

• Corticosteroids, oral contraceptives, and thyroid medications (may alter insulin effect)

• Diuretics and ACE inhibitors (may affect blood glucose levels)

Storage/Disposal

• Store unopened pens in refrigerator (2°C–8°C) – do not freeze

• Once opened, can be kept at room temperature (below 30°C) for up to 4 weeks

• Keep away from direct light and heat

• Dispose of used pens in a sharps container

Control Drug

Yes – NovoMix 50 is a prescription-only medicine and must be used under a doctor’s supervision.

Quick Tips

• Always check the insulin label before injection to avoid mix-ups

• Eat meals regularly to prevent hypoglycemia

• Keep a source of fast-acting sugar with you at all times

• Never stop or switch insulin type without consulting your doctor

• Regular exercise and a balanced diet enhance insulin effectiveness