Rocephin 500mg IM Injection – Broad-Spectrum Antibiotic | Ceftriaxone

Description

Rocephin 500mg IM Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic. It is administered via intramuscular injection and is used for the treatment of a wide range of bacterial infections. Rocephin works by inhibiting bacterial cell wall synthesis, making it highly effective against severe and resistant infections.

Ingredients

• Active Ingredient: Ceftriaxone Sodium (500mg)

• Inactive Ingredients: Sterile diluent for reconstitution (may vary by manufacturer)

Drug Class

• Third-Generation Cephalosporin Antibiotic

Dosage Form

• Injection (Intramuscular use)

• Strength: 500mg vial

Uses

• Treatment of bacterial infections such as:

  • Respiratory tract infections (pneumonia, bronchitis)

  • Urinary tract infections (UTIs)

  • Skin and soft tissue infections

  • Bone and joint infections

  • Intra-abdominal infections

  • Gonorrhea and pelvic inflammatory disease

  • Meningitis (bacterial)

  • Sepsis and bloodstream infections

• Pre- and post-surgical infection prevention

Dosage

• Adults: 500mg to 1g IM once daily, depending on severity of infection

• Gonorrhea (single-dose therapy): 250mg–500mg IM as a single dose

• Children/infants: Dose based on body weight and medical condition
  ⚠️ Dose must be prescribed by a healthcare professional

In Case of Overdose

• Symptoms: Seizures, irregular heartbeat, kidney or liver dysfunction

• Requires immediate emergency medical attention

Missed Dose

• If a scheduled dose is missed, administer as soon as remembered by a healthcare provider

• Do not double the dose

How To Use

• To be administered by a doctor or nurse deep into a large muscle (usually buttock or thigh)

• Reconstituted with sterile water or lidocaine (as recommended) before injection

• Do not self-inject without medical supervision

When Not to Use

• Allergy to ceftriaxone, cephalosporins, or penicillin antibiotics

• Newborns (≤28 days) with jaundice or receiving calcium-containing solutions

• Patients with severe liver/kidney impairment (unless closely monitored)

• History of severe antibiotic-associated diarrhea (colitis)

Side Effects

• Common: Injection site pain/swelling, diarrhea, nausea, rash

• Less common: Headache, dizziness, anemia

• Serious (rare): Severe allergic reaction, seizures, jaundice, severe diarrhea (C. difficile colitis)

Precautions & Warnings

• Use with caution in patients with:

  • Kidney or liver problems

  • Gastrointestinal conditions (especially colitis)

  • History of antibiotic allergy

• May interfere with blood/lab tests (glucose, Coombs test)

• Safe in pregnancy and breastfeeding only if prescribed by a doctor

Drug Interactions

• Calcium-containing injections (risk of precipitation, especially in neonates)

• Aminoglycosides (e.g., gentamicin) – may increase kidney toxicity

• Blood thinners (warfarin, heparin) – may increase bleeding risk

• Probenecid – may increase ceftriaxone concentration in blood

Storage/Disposal

• Store vials at room temperature (below 25°C), in a cool, dry place

• Protect from direct sunlight and moisture

• Use freshly reconstituted solution immediately

• Discard unused solution as per medical waste guidelines

Control Drug

• Not a controlled substance

• Prescription required

Quick Tips

• Complete the full course of treatment even if you feel better

• Report any severe diarrhea or allergic reaction immediately

• Do not mix with calcium-containing IV/IM solutions

• Must only be administered by a trained medical professional

• Drink plenty of fluids unless restricted by your doctor