Fortum 1 g Injection (Ceftazidime) – 1 Vial

Description

Fortum Injection contains Ceftazidime, a third-generation cephalosporin antibiotic. It is a broad-spectrum bactericidal agent effective against both Gram-positive and Gram-negative bacteria, with notable activity against Pseudomonas aeruginosa. Fortum is commonly used in serious bacterial infections, particularly in hospital or ICU settings.

Ingredients

• Active Ingredient: Ceftazidime (as pentahydrate) 1 g per vial

• Excipients: May contain sodium carbonate (to adjust pH)

Drug Class

• Antibiotic

• Subclass: Third-generation cephalosporin

Dosage Form

• Powder for Injection (to be reconstituted with sterile water)

• Strength: 1 g per vial

Uses / Indications

• Severe bacterial infections, including:

  • Respiratory tract infections (pneumonia, bronchitis)

  • Urinary tract infections

  • Skin and soft tissue infections

  • Bone and joint infections

  • Bacterial meningitis

  • Septicemia and bacteremia

  • Infections in neutropenic patients

  • Intra-abdominal infections, including peritonitis

  • Gynecological infections

• Effective particularly against Pseudomonas aeruginosa and other resistant organisms

Dosage

• Adults:

  • Usual dose: 1 g every 8 hours or 2 g every 12 hours by IV/IM injection

  • Severe infections: up to 2 g every 8 hours (maximum 9 g/day)

• Children (>2 months): 30–50 mg/kg every 8 hours

• Neonates: 30 mg/kg every 12 hours

• Dosage must be adjusted in renal impairment

In Case of Overdose

• Symptoms: Neurological effects (seizures, confusion, encephalopathy), renal dysfunction

• Treatment:

  • Stop drug immediately

  • Supportive care and symptomatic treatment

  • Hemodialysis may help eliminate drug

Missed Dose

• Administer as soon as remembered

• Do not double dose; resume normal schedule

How To Use / Administration Instructions

1. Reconstitute vial with sterile water for injection (usually 3 mL for IM, 10 mL for IV).

2. Solution should be clear to pale yellow.

3. Administer via intramuscular (IM) or intravenous (IV) injection/infusion.

4. Only trained healthcare professionals should prepare and inject.

When Not to Use / Contraindications

• Hypersensitivity to ceftazidime, other cephalosporins, or beta-lactam antibiotics (penicillins, carbapenems)

• History of severe allergic reaction (e.g., anaphylaxis) to antibiotics

Side Effects / Adverse Reactions

Common:

• Pain, redness, or swelling at injection site

• Diarrhea, nausea, vomiting

• Headache, dizziness

• Rash, itching

Serious (rare):

• Severe allergic reactions (anaphylaxis, angioedema)

• Clostridium difficile-associated diarrhea (pseudomembranous colitis)

• Seizures, encephalopathy (especially in renal impairment)

• Blood disorders (leukopenia, thrombocytopenia)

• Elevated liver enzymes

Precautions & Warnings

• Use cautiously in patients with renal impairment (dose adjustment required)

• Cross-reactivity with penicillins possible — use with caution in allergic patients

• Prolonged use may cause superinfections

• Monitor renal and hepatic function during long-term therapy

• Use during pregnancy only if clearly needed; passes into breast milk

Drug Interactions

• Aminoglycosides / loop diuretics (e.g., furosemide): ↑ risk of nephrotoxicity

• Chloramphenicol: antagonistic effect when used with ceftazidime

• Oral anticoagulants (e.g., warfarin): possible increased bleeding risk

• Probenecid: may reduce renal excretion, increasing ceftazidime levels

Storage / Disposal

• Store below 25°C in a dry place

• Protect from light and moisture

• Once reconstituted, use immediately or within manufacturer’s recommended time (usually within 24 hours if refrigerated)

• Dispose of unused solution according to medical waste protocols

Control Drug / Prescription Status

• Prescription-only medicine

• Not a controlled substance, but restricted to use under physician supervision

Quick Tips

• Complete the full course of therapy, even if you feel better

• Report severe diarrhea or allergic reactions immediately

• Do not self-inject; must be given by healthcare professionals

• Inform your doctor if you have kidney problems or are taking other antibiotics

• Drink plenty of fluids to support kidney function during therapy