Grasil Injection 500mg (Amikacin Sulfate) — 2ml Vial

Description

Grasil Injection contains Amikacin Sulfate 500mg/2ml, an aminoglycoside antibiotic used for the treatment of serious bacterial infections caused by susceptible Gram-negative organisms and some Gram-positive bacteria. It is typically reserved for infections that are resistant to other antibiotics.

Ingredients

• Active ingredient: Amikacin sulfate 500mg per 2ml

• Excipients: Sodium bisulfite, sodium citrate, sulfuric acid (for pH adjustment), and water for injection

Drug Class

• Aminoglycoside antibiotic

Dosage Form

• Sterile solution for intramuscular (IM) or intravenous (IV) injection

Uses / Indications

• Severe Gram-negative bacterial infections (e.g., Pseudomonas, E. coli, Klebsiella, Enterobacter, Proteus)

• Infections of:

  • Respiratory tract

  • Urinary tract

  • Intra-abdominal area (including peritonitis)

  • Skin and soft tissues

  • Bones and joints

• Septicemia (bloodstream infections)

• Meningitis (as part of combination therapy)

• Used when bacteria are resistant to other aminoglycosides or antibiotics

Dosage

• Adults: 15 mg/kg/day in 2–3 divided doses IM or IV

• Children: 15–20 mg/kg/day in 2–3 divided doses

• Neonates: 10 mg/kg loading dose, then 7.5 mg/kg every 12 hours

• Duration: 7–10 days (as directed by physician)

• Dosage adjusted for renal impairment

In Case of Overdose

• Symptoms: Hearing loss, dizziness, balance problems, kidney impairment, respiratory paralysis (rare)

• Management: Stop drug immediately, provide supportive treatment, consider hemodialysis in severe cases

Missed Dose

• If a dose is missed, take it as soon as possible under medical advice

• Do not double dose — continue with the next scheduled dose

How To Use

• Given by intramuscular injection or slow intravenous infusion (30–60 minutes)

• Should only be administered by trained healthcare professionals

• Adequate hydration is recommended during therapy

When Not to Use / Contraindications

• Hypersensitivity to amikacin or other aminoglycosides

• Patients with severe renal impairment (unless dose is adjusted)

• Pregnancy (unless benefits outweigh risks — risk of fetal harm)

• History of ototoxicity or neuromuscular disorders (e.g., myasthenia gravis)

Side Effects

Common:

• Pain at injection site

• Nausea, vomiting

• Mild headache, dizziness

Serious:

• Nephrotoxicity (kidney damage)

• Ototoxicity (hearing loss, tinnitus, vertigo)

• Neuromuscular blockade → respiratory paralysis (rare)

• Allergic reactions (rash, itching, swelling, difficulty breathing)

Precautions & Warnings

• Regular monitoring of kidney function (serum creatinine) and hearing tests during prolonged therapy

• Use with caution in elderly patients and those with pre-existing renal disease

• Maintain adequate hydration to minimize toxicity risk

• Use cautiously with other nephrotoxic or ototoxic drugs (e.g., furosemide, cisplatin, vancomycin)

Drug Interactions

• Nephrotoxic drugs: Amphotericin B, vancomycin, cisplatin — ↑ kidney damage risk

• Ototoxic drugs: Loop diuretics (furosemide, ethacrynic acid) — ↑ risk of hearing loss

• Neuromuscular blockers: Additive muscle relaxant effect → respiratory issues

• Other aminoglycosides: Avoid combination due to cumulative toxicity

Storage / Disposal

• Store below 25°C in a dry place, protect from light

• Do not freeze

• Keep out of reach of children

• Discard any unused portion safely according to hospital protocol

Control Drug / Prescription Status

• Prescription-only medicine

Quick Tips

• Grasil is a potent antibiotic used only for serious infections resistant to other treatments

• Do not self-administer — must be given in a hospital or clinic

• Drink plenty of fluids during treatment to protect kidneys

• Report any ringing in ears, hearing loss, or reduced urine output immediately