Insuget N (100 IU/ml) 10ml Vial – Human Insulin Isophane Injection

Description

Insuget N is a human insulin isophane suspension (NPH insulin) used for the treatment of diabetes mellitus. It is an intermediate-acting insulin designed to control blood glucose levels by promoting glucose uptake in tissues and inhibiting glucose production in the liver. It is supplied in a 10 ml multi-dose vial for subcutaneous injection.

Ingredients

• Active Ingredient: Human Insulin Isophane (NPH Insulin) – 100 IU/ml

• Excipients: Zinc chloride, glycerol, phenol or m-cresol (preservative), protamine sulfate, sodium phosphate buffer, water for injection (may vary by manufacturer).

Drug Class

• Intermediate-acting insulin

• Antidiabetic agent

Dosage Form

• Injectable suspension in 10 ml vial (multi-dose)

• Strength: 100 IU/ml

Uses / Indications

• Treatment of diabetes mellitus (Type 1 and Type 2) when insulin therapy is required

• Provides basal glycemic control (covers glucose needs between meals and during the night)

• May be used in combination with short-acting insulins or oral antidiabetic drugs for better control

Dosage

• Individualized based on blood glucose monitoring, diet, and physician’s guidance

• Typical starting total daily insulin dose: 0.2 – 0.6 IU/kg body weight/day (combined regimen)

• Insuget N is often administered once or twice daily via subcutaneous injection

• Should not be administered intravenously

In Case of Overdose

• Overdose can lead to severe hypoglycemia with symptoms such as sweating, tremor, confusion, palpitations, seizures, or loss of consciousness

• Immediate management:

  • Give fast-acting carbohydrate orally if the patient is conscious

  • If unconscious: administer glucagon injection or IV glucose

  • Continuous monitoring until recovery

Missed Dose

• If a dose is missed, monitor blood glucose and take corrective action per doctor’s advice

• Never double the next dose to compensate, as this may cause hypoglycemia

How To Use / Administration Instructions

1. Roll the vial gently between palms before use (do not shake vigorously).

2. Inspect suspension; it should appear uniformly cloudy/white after mixing.

3. Inject subcutaneously (abdomen, thigh, upper arm, or buttock); rotate injection sites to avoid lipodystrophy.

4. Do not inject into a vein or muscle unless specifically advised.

5. Use sterile syringes and needles; do not share.

When Not to Use / Contraindications

• Known hypersensitivity to human insulin or formulation components

• During episodes of hypoglycemia

• IV administration is contraindicated

Side Effects / Adverse Reactions

Common:

• Injection site reactions (pain, redness, swelling)

• Hypoglycemia (most frequent adverse effect)

Less common / serious:

• Lipodystrophy at injection sites

• Allergic reactions (rash, itching, swelling)

• Rare systemic allergic reactions including anaphylaxis

Precautions & Warnings

• Monitor blood glucose regularly; adjust dose with changes in diet, activity, or illness

• Use with caution in patients with renal or hepatic impairment

• Avoid alcohol intake (may worsen hypoglycemia)

• Pregnancy & lactation: insulin requirements may change; medical supervision required

• Carry glucose tablets or sugar in case of hypoglycemia

Drug Interactions

• Increased hypoglycemic effect: oral antidiabetic drugs, ACE inhibitors, beta-blockers, MAO inhibitors, sulfonamides, alcohol

• Decreased effect: corticosteroids, diuretics, thyroid hormones, oral contraceptives, sympathomimetics

• Beta-blockers may mask hypoglycemia symptoms (e.g., rapid heartbeat)

Storage / Disposal

• Store at 2°C – 8°C (refrigerated); do not freeze

• Protect from direct heat and light

• Once in use, may be kept at room temperature (<25°C) for up to 28 days (follow label instructions)

• Discard vial after 28 days of opening or if suspension looks abnormal

• Dispose of needles/syringes in sharps container

Control Drug / Prescription Status

• Prescription only medicine

• Must be used under the supervision of a healthcare professional

Quick Tips

• Always check vial appearance before use; insulin should look evenly cloudy when mixed

• Rotate injection sites to prevent skin complications

• Keep a blood glucose monitoring diary and carry emergency sugar at all times

• Do not stop insulin suddenly without medical advice

• Inform doctor before surgery, illness, or changes in diet/exercise