Rocephin 500mg IV Injection – Broad-Spectrum Antibiotic | Ceftriaxone

Description

Rocephin 500mg IV Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic. It is administered via intravenous (IV) injection and is highly effective against a wide variety of bacterial infections. Rocephin works by inhibiting bacterial cell wall synthesis, which stops the growth of harmful bacteria. It is often used in hospitals for moderate to severe infections that require fast-acting treatment.

Ingredients

• Active Ingredient: Ceftriaxone Sodium (500mg)

• Inactive Ingredients: Sterile diluent for reconstitution (varies by manufacturer)

Drug Class

• Cephalosporin Antibiotic (Third Generation)

Dosage Form

• Injection (Intravenous)

• Strength: 500mg vial

Uses

• Treatment of bacterial infections, including:

  • Respiratory tract infections (pneumonia, bronchitis)

  • Urinary tract infections (UTIs)

  • Skin and soft tissue infections

  • Bone and joint infections

  • Abdominal infections (peritonitis)

  • Gonorrhea and pelvic inflammatory disease

  • Meningitis (bacterial)

  • Sepsis and bloodstream infections

• Surgical infection prevention (pre- and post-operative)

Dosage

• Adults: 500mg to 1g IV once daily, depending on severity of infection

• Children/Infants: Dose based on weight (consult physician)

• Gonorrhea treatment: Single dose of 250–500mg IV
  ⚠️ Dosage must be prescribed by a healthcare professional only.

In Case of Overdose

• Symptoms: Seizures, irregular heart rhythm, liver/kidney dysfunction

• Immediate emergency treatment is required

Missed Dose

• If a scheduled dose is missed in a hospital setting, the healthcare provider will adjust dosing

• Do not double dose

How To Use

• To be administered intravenously by a doctor or nurse

• Vial must be reconstituted with a compatible diluent before injection

• Must be injected slowly into a vein or infused through an IV drip

• Not for self-administration

When Not to Use

• Allergy to ceftriaxone, cephalosporins, or penicillin antibiotics

• Newborns (≤28 days) with hyperbilirubinemia (jaundice)

• Neonates requiring calcium-containing IV solutions (risk of precipitation)

• Severe liver or kidney impairment (unless closely monitored)

• History of severe antibiotic-related diarrhea (colitis)

Side Effects

• Common: Pain at injection site, nausea, mild diarrhea, rash

• Less common: Dizziness, headache, anemia, mild liver enzyme elevation

• Serious (rare): Severe allergic reactions, seizures, jaundice, C. difficile colitis

Precautions & Warnings

• Use with caution in patients with kidney/liver problems

• Monitor in patients with gastrointestinal issues (colitis)

• May interfere with some lab tests (e.g., blood sugar, Coombs test)

• Safe in pregnancy and breastfeeding only under medical supervision

• Avoid rapid IV push administration – should be infused slowly

Drug Interactions

• Calcium-containing IV solutions – risk of precipitation

• Aminoglycosides (e.g., gentamicin) – increased kidney toxicity risk

• Blood thinners (warfarin, heparin) – increased bleeding risk

• Probenecid – may increase ceftriaxone blood levels

Storage/Disposal

• Store below 25°C in a cool, dry place

• Protect from direct sunlight and moisture

• Use freshly prepared solution immediately after reconstitution

• Dispose of unused vials as per hospital medical waste guidelines

Control Drug

• Not a controlled substance

• Prescription-only medicine

Quick Tips

• Complete the full prescribed course even if you feel better

• Must be administered only by trained medical professionals

• Inform your doctor of any allergies before treatment

• Do not mix with calcium-containing IV solutions

• Stay hydrated unless otherwise directed by your doctor